AI Article Synopsis
- Amphiphilic triblock copolymers with Fe(III)-catecholate complexes are developed into spherical (SMN) and cylindrical (CMN) micellar nanoparticles, showing promise as new T1-weighted imaging agents with high relaxivity and low cytotoxicity.
- The relaxivity of both SMN and CMN surpasses traditional gadolinium chelates across various magnetic field strengths, indicating better performance in MRI.
- Shape differences between SMN and CMN lead to varying interactions with HeLa cells, with cylindrical particles (CMN) showing improved uptake and imaging contrast, suggesting that controlling nanoparticle shape can enhance their use as contrast agents in biomedical applications.
Article Abstract
Amphiphilic triblock copolymers containing Fe(III) -catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles (SMN and CMN, respectively) are described as new T1-weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fluids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic field strengths. Interestingly, shape-dependent behavior is observed in terms of the particles' interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN. These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441847 | PMC |
| http://dx.doi.org/10.1002/smll.201502754 | DOI Listing |
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