AI Article Synopsis
- The study aimed to investigate the relationship between urinary 11-dehydro-thromboxane B2 (11dhTxB2) levels and how well aspirin works in patients with type 2 diabetes and coronary artery disease (CAD).
- Involving 169 elderly patients, the study measured urinary 11dhTxB2 levels to classify them into high aspirin platelet reactivity (HAPR) and No-HAPR groups, with high levels indicating low response to aspirin.
- Results showed that patients had significantly lower urinary 11dhTxB2 levels after aspirin treatment, and those in the HAPR group experienced worse outcomes, suggesting urinary 11dhTxB2 levels could be a useful tool for assessing aspirin effectiveness in this
Article Abstract
Objective: To elucidate the correlation between urinary 11-dehydro-thromboxane B2 (11dhTxB2) and clinical efficacy of aspirin treatment in patients with type 2 diabete and coronary artery disease (CAD).
Methods: In this prospective cohort study, 169 aged patients with type 2 diabete accompanying CAD in Peking University First Hospital were enrolled. The level of urinary 11dhTxB2 was detected using enzyme-linked immuno-sorbent assay. Low aspirin response or high on aspirin platelet reactivity (HAPR) was defined as urinary 11dhTxB2>1 500 ng/g. All the included patients were divided into two groups based on the results, HAPR group and No-HAPR group.
Results: Baseline urinary 11dhTxB2 of the patients with type 2 diabete accompanying CAD was (3 687±3 052) ng/g, while the urinary 11dhTxB2 was (1 954±859) ng/g in patients after 100 mg/d aspirin treatment (P<0.001). Prevalence of HAPR in patients with type 2 diabete accompanying CAD were 32.5%. Within a mean follow-up time of 12 months, the outcomes occurred more frequently in HAPR group than in No-HAPR group (P<0.05).
Conclusion: Urinary 11dhTxB2 can be recognized as an effective indicator in evaluating aspirin clinical efficacy of patients with type 2 diabete accompanying CAD.
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