Modeling Bacterial Infection Phenomena.

Curr Comput Aided Drug Des

Institute for Structural Biology, Drug Discovery and Development, Life Sciences, Virginia Commonwealth University, Richmond, VA, 23298, USA.

Published: October 2016

A series of cellular automata models of bacteria were created, where encounters with models of the immune system and a model of an antibiotic drug were present. The dose of the antibiotic, its potency and the timeliness of its administration were variables. The emergence of antibiotic resistance by the bacteria was an outcome associated with the administration of the drug. The models created in these studies were found to closely relate to clinical experiences, making the general model useful for further simulation studies.

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http://dx.doi.org/10.2174/1573409912666151218155921DOI Listing

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