AI Article Synopsis
- The study evaluated the cost-effectiveness of the quadrivalent HPV vaccine in Argentina from a health system perspective, focusing on its impact on disease incidence and healthcare costs.
- A dynamic transmission model indicated that the vaccine could significantly reduce the risk of cervical cancer (60%) and genital warts (67%), providing an incremental benefit of 0.00234 QALY per person at a cost of US$2.36.
- The findings confirmed the vaccine's cost-effectiveness, with a ratio of US$1007.55 per QALY gained, well below the GDP per capita threshold of US$15,009.
Article Abstract
Objective: To assess the cost-effectiveness of the quadrivalent vaccine against human papillomavirus (HPV) in Argentina from the health system perspective.
Materials And Methods: A dynamic transmission model was used to estimate the impact of the vaccine on the incidence of cervical cancer, warts, and other HPV related diseases; in quality adjusted life years (QALYs); and in healthcare costs.
Results: Vaccination could reduce the risk of cervical cancer by 60% and by 67% the risk of genital warts. Compared to a non-vaccine scenario, the immunization strategy showed an incremental benefit of 0.00234 QALY per person at an incremental cost of US$2.36, resulting in an incremental cost-effectiveness ratio of US$1007.55 per QALY gained. Sensitivity analysis proved the robustness of these results.
Conclusions: Immunization with the quadrivalent vaccine was a cost-effective intervention in Argentina, and it was far below the threshold of one gross domestic product per capita (US$15 009) per QALY gained.
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