AI Article Synopsis
- The study aimed to investigate how negative emotions impact serum levels of adrenocorticotropic hormone (ACTH) and neuropeptide Y (NPY) in patients with hepatitis B liver cirrhosis (HBLC).
- A total of 617 HBLC patients were divided into two groups: one experiencing negative emotions and another without, and their liver function and hormone levels were compared.
- Findings revealed no significant difference in ACTH levels based on emotional state; however, patients with negative emotions had lower serum NPY levels, indicating a potential link between negative emotions and NPY rather than ACTH.
Article Abstract
Objective: To explore the effect of negative emotions on serum levels of adrenocorticotropic hormone (ACTH) and neuropeptide Y (NYP) in hepatitis B liver cirrhosis (HBLC) patients.
Methods: Totally 617 HBLC patients were assigned to the negative emotion group (415 cases) and the non-negative emotion group (202 cases) judged by negative emotions. Case numbers of various grading Child-Pugh were recorded in the two groups. Their liver functions were compared between the two groups. Serum levels of ACTH and NPY were detected using double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in the two groups.
Results: There was no statistical difference in Child-Pugh grading between the two groups (χ2 = 0.65, P = 0.72). Compared with the non-negative emotional group, serum ACTH levels decreased significantly in the negative emotion group with statistical difference (P < 0.05). There was no statistical difference in serum ACTH levels between the two groups (P > 0.05).
Conclusion: The negative emotion of HBLC patients was not related to the serum ACTH level, but to relatively lower-concentration serum NPY levels.
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