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Synthesis and Characterization of Two Sparfloxacin Crystalline Salts: Enhancing Solubility and In Vitro Antibacterial Activity of Sparfloxacin.
Pharmaceutics
November 2024
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
: To improve the solubility and permeability of Sparfloxacin (SPX) and enhance its antimicrobial activity in vitro, two unreported pharmaceutical crystalline salts were synthesized and characterized in this paper. One is a hydrated crystal of Sparfloxacin with Pimelic acid (PIA), another is a hydrated crystal of Sparfloxacin with Azelaic acid (AZA), namely, SPX-PIA-HO (2CHFNO·CHO·2HO) and SPX-AZA-HO (4CHFNO·2CHO·5HO). : The structure and purity of two crystalline salts were analyzed using solid-state characterization methods such as single-crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and infrared spectroscopy.
View Article and Find Full Text PDFMicrobial diversity and metabolomics analysis of colon contents exposed to cadmium and polystyrene microplastics.
Ecotoxicol Environ Saf
December 2024
Department of Veterinary Surgery, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:
Cadmium and microplastics, common pollutants, can accumulate in the body, impacting the intestinal barrier and harming livestock breeding. In order to explore the damage mechanism of cadmium and cadmium combined microplastic on the colon of mice, 60 mice were divided into three groups: The control group (0.2 mL of saline), cadmium group (Cd group, 0.
View Article and Find Full Text PDFThe effect of azelaic acid on AlCl-induced neurocognitive impairments and molecular changes in the hippocampus of rats.
Acta Neuropsychiatr
December 2024
Department of Pharmacology & Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.
Objectives: Cognitive function plays a pivotal role in assessing an individual's quality of life. This research aimed to investigate how azelaic acid (AzA), a natural dicarboxylic acid with antioxidant and anti-inflammatory properties, affects aluminium chloride (AlCl)-induced behavioural changes and biochemical alterations in the hippocampus of rats.
Methods: Thirty-two male Wistar rats divided into four groups received distilled water, AzA 50 mg/kg, AlCl 100 mg/kg and AzA plus AlCl, respectively, by oral gavage for 6 weeks.
Zuojin Pill Alleviates Precancerous Lesions of Gastric Cancer by Modulating the MEK/ERK/c-Myc Pathway: An Integrated Approach of Network Pharmacology, Molecular Dynamics Simulation, and Experimental Validation.
Drug Des Devel Ther
December 2024
School of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China.
Background: Precancerous lesions of gastric cancer (PLGC) represent critical stages in gastric cancer progression, with a high risk of malignancy. Current treatments, such as Helicobacter pylori eradication, show limited efficacy in reversing precancerous molecular changes. Zuojin Pill (ZJP), a traditional Chinese medicine, has demonstrated potential for treating digestive disorders and may offer a promising approach for PLGC intervention.
View Article and Find Full Text PDFIn this work, we developed a general synthesis method for the water-soluble lanthanide ion-doped NaYF upconversion (UC) nanoparticles (NPs) using triethylene glycol (TEG) as a high temperature solvent and diacid as a surfactant. Since the boiling point of the TEG is as high as 289.4 °C, the synthesis temperature can be correspondingly increased to a higher temperature that is a bit lower than this one.
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