A rapid and sensitive (100%) matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) assay was developed to detect OXA-48-type producers, using 161 previously characterized clinical isolates. Ertapenem was monitored to detect carbapenem resistance, and temocillin was included in the assay as a marker for OXA-48-producers. Structural analysis of temocillin is described. Data are obtained within 60 min.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767963 | PMC |
| http://dx.doi.org/10.1128/JCM.02496-15 | DOI Listing |
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