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Single-Cell Lineage Tracing and Clonal State-Fate Analysis.
Methods Mol Biol
January 2025
Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Catalonia, Spain.
Lineage tracing has significantly advanced our comprehension in many areas of biology, such as development or immunity, by precisely measuring cellular processes like migration, division, or differentiation across labeled cells and their progeny. Traditional recombinase-based prospective lineage tracing is limited by the need for a priori cell type information and is constrained in the numbers of clones it can simultaneously track. In this sense, clonal lineage tracing with integrated random barcodes offers a robust alternative, enabling researchers to label and track a vast array of cells and their progeny over time.
View Article and Find Full Text PDFImproving search strategies in bibliometric studies on machine learning in renal medicine.
Int Urol Nephrol
December 2024
Department of Thoracic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan Province, China.
This paper evaluated the bibliometric study by Li et al. (Int Urol Nephrol, 2024) on machine learning in renal medicine. Although the study claims to summarize the forefront trends and hotspots in this field, several key issues require further clarification to effectively guide future research.
View Article and Find Full Text PDFToward personalized exercise prescriptions for blood pressure management: insights from a comprehensive meta-analysis.
Hypertens Res
December 2024
Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
A comment on the physiological basis for longitudinal motion of the arterial wall.
Am J Physiol Heart Circ Physiol
December 2024
Department of Translational Medicine, Lund University, Sweden.
The longitudinal motion and the intramural shear strain of the arterial wall increase dramatically in response to blood pressure, thereby impacting the vascular wall microenvironment. Exposure to a sedentary lifestyle has been identified as an independent risk factor for cardiovascular disease, but it has been shown that intermittent physical activity embedded into everyday life is enough to improve cardiovascular health. Marked changes in longitudinal motion already at low workload may explain this finding.
View Article and Find Full Text PDFReply to comment on 'Sarcopenic obesity in patients with head and neck cancer is predictive of critical weight loss during radiotherapy' (BJN-2-2024-1107).
Br J Nutr
December 2024
Department of Nutrition, Dietetics and Food, School of Clinical Sciences, Monash University, Clayton, VIC3168, Australia.
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