AI Article Synopsis
- Sandfly fever group viruses belong to the genus Phlebovirus and are known to affect military troops and indigenous populations worldwide.
- The Sand Fly Fever Virus Antigen Assay is a rapid test that successfully detects multiple viruses including the Naples and Toscana viruses, as well as several other phleboviruses.
- Laboratory results indicate that this assay is specific and does not yield false positives, making it a promising tool for quickly identifying infected sand flies in the field.
Article Abstract
Sandfly fever group viruses in the genus Phlebovirus (family Bunyaviridae) are widely distributed across the globe and are a cause of disease in military troops and indigenous peoples. We assessed the laboratory sensitivity and specificity of the Sand Fly Fever Virus Antigen Assay, a rapid dipstick assay designed to detect sandfly fever Naples virus (SFNV) and Toscana virus (TOSV) against a panel of phleboviruses. The assay detected SFNV and TOSV, as well as other phleboviruses including Aguacate, Anahanga, Arumowot, Chagres, and Punta Toro viruses. It did not detect sandfly fever Sicilian, Heartland, Rio Grande, or Rift Valley fever viruses. It did not produce false positive results in the presence of uninfected sand flies (Lutzomyia longipalpis) or Cache Valley virus, a distantly related bunyavirus. Results from this laboratory evaluation suggest that this assay may be used as a rapid field-deployable assay to detect sand flies infected with TOSV and SFNV, as well as an assortment of other phleboviruses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111559 | PMC |
| http://dx.doi.org/10.2987/moco-31-04-380-383.1 | DOI Listing |
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