The United States President's Emergency Plan for AIDS Relief (PEPFAR) emphasizes health systems strengthening as a cornerstone of programmatic success. Health systems strengthening, among other things, includes effective capacity building for clinical care, administrative management and public health practice. Avante Zambézia is a district-level in-service training program for administrative staff. It is associated with improved accounting practices and human resources and transportation management but not monitoring and evaluation. We discuss other examples of successful administrative training programs that vary in the proportion of time that is spent learning on the job and the proportion of time spent in classrooms. We suggest that these programs be more rigorously evaluated so that lessons learned can be generalized to other countries and regions.
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http://dx.doi.org/10.15171/ijhpm.2015.136 | DOI Listing |
Clin Pharmacol Ther
January 2025
Zydus Therapeutics Inc., Pennington, New Jersey, USA.
Saroglitazar magnesium, a dual PPAR α/γ agonist, currently in Phase III for treating primary biliary cholangitis (PBC), was evaluated for its pharmacokinetic (PK) profile, safety, and pharmacodynamics in participants with cholestatic liver disease (CLD) across different levels of hepatic impairment (HI) and participants with severe renal impairment (RI). Three PK studies comparing saroglitazar with healthy controls were conducted: Study 1 involved daily oral doses of 1 or 2 mg for 4 weeks in 12 PBC cirrhosis participants with mild or moderate HI; Study 2 assessed single-dose PK (2 or 4 mg) in eight non-cirrhotic CLD participants; Study 3 evaluated single-dose PK (2 mg) in eight participants with severe RI. On day 1, saroglitazar exposure increased by 14.
View Article and Find Full Text PDFCancers (Basel)
April 2024
Department of Genetics, Faculty of Medicine at Ribeirão Preto, University of São Paulo (FMRP-USP), Ribeirão Preto 14049-900, SP, Brazil.
Prostate cancer (PCa) is an immunologically cold tumor and the molecular processes that underlie this behavior are poorly understood. In this study, we investigated a primary cohort of intermediate-risk PCa ( = 51) using two NanoString profiling panels designed to study cancer progression and immune response. We identified differentially expressed genes (DEGs) and pathways associated with biochemical recurrence (BCR) and clinical risk.
View Article and Find Full Text PDFFront Oncol
October 2023
Diagnostic Development, Ontario Institute for Cancer Research, Toronto, ON, Canada.
The diverse clinical outcomes of prostate cancer have led to the development of gene signature assays predicting disease progression. Improved prostate cancer progression biomarkers are needed as current RNA biomarker tests have varying success for intermediate prostate cancer. Interest grows in universal gene signatures for invasive carcinoma progression.
View Article and Find Full Text PDFAnim Reprod
June 2023
Departamento de Clínica e Cirurgia Veterinária, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista "Júlio de Mesquita Filho", Jaboticabal, SP, Brasil.
Cien Saude Colet
January 2022
Programa de Pós-Graduação em Geografia, Universidade Federal Fluminense. Rua Gal. Milton Tavares s/n Instituto de Geociências, Campus Praia Vermelha Boa Viagem. 24210-346 Niterói RJ
This article reflects on the limits and possibilities for articulating the anti-asylum struggle with participatory city master plans (PMPs) in Brazil with the aim of helping enhance anti-asylum care in liberty and guaranteeing the rights of people experiencing mental suffering. Departing from the premise that the city is neither a therapeutic nor a caring environment, this analysis seeks to weave together the challenges of "living in liberty" with urban planning policies guided by PMPs. To this end, we analyzed terms pertaining to the anti-asylum struggle and Brazil's mental health reform in the PMPs of the 15 highest-scoring cities in the Connected Smart Cities Ranking.
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