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A Prospective Cohort Study on the Effect of Antiseizure Medications on Thyroid Function in Children Aged 6 Months to 12 Years with Epilepsy.
Sultan Qaboos Univ Med J
November 2024
Department of Pediatrics, Mediclinic City Hospital, Mohammed Bin Rashid University of Medicine & Health Sciences, Dubai, UAE.
Objectives: This study aimed to explore the effect of antiseizure medications (ASM) on thyroid function in children with epilepsy.
Methods: A prospective study involving children between 6 months and 12 years of age with new-onset seizures who took ASM within 2 months was conducted in the Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India, between August 2019 to March 2022. Thyroid function tests-free T3, free T4 and thyroid stimulating hormone (TSH)-were done at baseline and after completing 3 months by competitive immunoassay using direct chemiluminescent technology.
Impact of interaction among antiseizure medication polytherapy, clinical, sociodemographic and psychological factors on quality of life in patients with epilepsy: A systematic review.
Epilepsy Behav
January 2025
Institut d'Investigació en Psicologia dels Recursos Humans, del Desenvolupament Organitzacional i de La Qualitat de Vida Laboral (IDOCAL)/Department of Psychobiology, Psychology Center, Universitat de València, Valencia, Spain. Electronic address:
Introduction: Drug-resistant epilepsy usually requires the use of polytherapy with antiseizure medications (ASMs) for management, which could involve side and adverse effects that may impact quality of life (QOL). This systematic review summarizes the evidence about the relationship between ASM polytherapy and QOL in epilepsy patients, considering clinical, sociodemographic, and psychological variables.
Method: This review followed the PRISMA guidelines and was registered in PROSPERO.
Trends of antiseizure medication utilization among pregnant people in four Canadian provinces from 1998 to 2023; a study from the Canadian mother-child cohort active surveillance initiative (CAMCCO).
Front Pharmacol
November 2024
College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
Article Synopsis
- The study examines the use of antiseizure medications (ASMs) among pregnant individuals in four Canadian provinces over 20 years, focusing on trends and patterns in ASM usage among those with and without epilepsy.
- Results showed that only 0.7% of the pregnant population had epilepsy, with 1.7% exposed to ASMs; notable increases in ASM use were observed among those without epilepsy, especially in Manitoba, Saskatchewan, and Alberta.
- The analysis also revealed shifts in ASM drug classes, with a decline in older medications like carbamazepine and a rise in newer options like lamotrigine, while usage patterns varied by province and trimester.
Clinical and histopathological features of immune checkpoint inhibitor-induced lung toxicity.
Virchows Arch
November 2024
Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA.
A new era in cancer therapy emerged with the arrival of immune-checkpoint inhibitors (ICIs), followed by a new cadre of immune-related adverse events that affect up to 40% of patients. Literature on the pathological features associated with these events is still limited. Therefore, to expand our knowledge of the histopathologic spectrum of pulmonary changes, we conducted a case study series analysis on 16 non-neoplastic lung samples collected during or after ICI therapy.
View Article and Find Full Text PDFVitamin D Supplementation for Children with Epilepsy on Antiseizure Medications: A Randomized Controlled Trial.
Children (Basel)
September 2024
Department of Pediatrics, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
Background: Antiseizure medications (ASMs) are crucial for managing epilepsy in children. However, a well-documented side effect of ASMs is their impact on bone health, often due to interference with vitamin D metabolism. This can lead to vitamin D deficiency in children with epilepsy.
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