AI Article Synopsis
- Effective antiretroviral therapy has significantly increased the lifespan of HIV-infected patients, but this has led to a rise in chronic non-infective diseases, particularly chronic kidney disease.
- The development of kidney disease in HIV patients is influenced by factors unique to HIV, such as the virus's direct impact, the level of immunodeficiency, and the toxicity of medications.
- Additionally, common chronic conditions like diabetes, hypertension, and hyperlipidemia pose further risks for kidney health in this population, with certain unique characteristics linked to the virus and treatment.
Article Abstract
Significant survival prolongation in HIV-infected patients due to effective antiretroviral therapy is connected with increasing prevalence of chronic non-infective diseases in this population, among them chronic kidney disease. The pathogenesis of kidney disease in the setting of HIV includes conditions specific for HIV infection: direct effect of the virus, stage of immunodeficiency and drug toxicity. Chronic comorbidities, such as diabetes mellitus, hypertension, and hyperlipidemia, are additional significant risk factors of kidney disease. In HIV-infected individuals some distinct features of these conditions are observed, which are partly related to the virus and antiretroviral therapy. The article summarizes the effect of comorbidities on kidney function in HIV-infected persons.
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| http://dx.doi.org/10.5604/17322693.1186343 | DOI Listing |
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