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| http://dx.doi.org/10.1371/journal.ppat.1005352 | DOI Listing |
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Metabolomic heterogeneity of ageing with ethnic diversity: a step closer to healthy ageing.
Metabolomics
December 2024
Centre for Metabolomics Research (CMR), Department of Biochemistry, Cell, and Systems Biology, Institute of Systems Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Introduction: Outside of case-control settings, ethnicity specific changes in the human metabolome are understudied especially in community dwelling, ageing men. Characterising serum for age and ethnicity specific features can enable tailored therapeutics research and improve our understanding of the interplay between age, ethnicity, and metabolism in global populations.
Objective: A metabolomics approach was adopted to profile serum metabolomes in middle-aged and elderly men of different ethnicities from the Northwest of England, UK.
Immunoglobulin G N-glycan markers of mild cognitive impairment in a Chinese population with cerebrovascular stenosis: A case-control study.
Int Immunopharmacol
January 2025
School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China; The Second Affiliated Hospital of Shandong First Medical University, Taian 271099, China; School of Public Health, Jining Medical College, Jining 272067, China. Electronic address:
Background: Immunoglobulin G (IgG) N-glycans have been shown to regulate the inflammatory response in the context of disease. In recent years, it has been found to be associated with several neurodegenerative disorders. In this study, we examined the relationship between IgG N-glycans and mild cognitive impairment (MCI) in a high-risk population for MCI, specifically patients with cerebrovascular stenosis.
View Article and Find Full Text PDFAbsence of the dolichol synthesis gene DHRSX leads to N-glycosylation defects in Lec5 and Lec9 Chinese hamster ovary cells.
J Biol Chem
December 2024
Laboratory for Molecular Diagnosis, Center for Human Genetics, KU Leuven, Leuven, Belgium. Electronic address:
Article Synopsis
- - Glycosylation-deficient CHO cell lines, specifically Lec5 and Lec9, have been key to understanding N-glycosylation, but the reasons behind their glycosylation defects remained unclear until now.
- - Dolichol synthesis from polyprenol was found to occur in three steps involving the enzymes DHRSX and SRD5A3, with Lec5 and Lec9 cells showing increased levels of polyprenol and decreased dolichol, indicating a deficiency in DHRSX.
- - Long-read genome sequencing revealed that the DHRSX gene was missing in Lec5 and Lec9 cells, while the SRD5A3 gene was intact, confirming that the glycosylation defects
A Bioorthogonal Precision Tool for Human -Acetylglucosaminyltransferase V.
J Am Chem Soc
October 2024
Department of Chemistry, Imperial College London, London W12 0BZ, U.K.
Correct elaboration of N-linked glycans in the secretory pathway of human cells is essential in physiology. Early N-glycan biosynthesis follows an assembly line principle before undergoing crucial elaboration points that feature the sequential incorporation of the sugar -acetylglucosamine (GlcNAc). The activity of GlcNAc transferase V (MGAT5) primes the biosynthesis of an N-glycan antenna that is heavily upregulated in cancer.
View Article and Find Full Text PDFProteome and Glycoproteome Analyses Reveal Regulation of Protein Glycosylation Site-Specific Occupancy and Lysosomal Hydrolase Maturation by -Glycan-Dependent ER-Quality Control.
J Proteome Res
October 2024
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
Article Synopsis
- * In studies using cells lacking the MOGS gene (encoding an enzyme important for glycan processing) and components of the CANX/CALR cycle, significant changes were observed in protein expression and glycosylation patterns, particularly affecting oligomannosidic -glycans.
- * The research revealed that lysosomal hydrolases in the defective cells were poorly modified and improperly secreted, highlighting the important role of the CANX/CALR cycle in
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