Aim: To investigate the effects of rhubarb enema treatment using a 5/6 nephrectomized rat model and study its mechanisms.
Methods: Twenty-eight Sprague Dawley rats were divided into three groups: sham operation group (n = 8), 5/6 nephrectomized (5/6Nx) (n = 10), and 5/6Nx with rhubarb enema treatment (n = 10). The rhubarb enema was continuous for 1.0 month. Serum creatinine, serum indoxyl sulfate (IS) level, renal pathology, tubulointerstitial fibrosis, and renal oxidative stress were assessed.
Results: 5/6Nx rats showed increasing levels of serum creatinine and severe pathological lesions. Their serum creatinine levels obviously decreased after rhubarb enema treatment (P < 0.05 vs 5/6Nx group). The administration of rhubarb enema attenuated the histopathological changes in 5/6Nx rats. In addition, 5/6Nx rats showed an enhanced extent of tubulointerstitial fibrosis compared with sham rats, and administration of rhubarb enema to 5/6Nx rats ameliorated tubulointerstitial fibrosis. 5/6Nx rats showed increased serum levels of IS, renal oxidative stress, and NF-κB compared with sham rats, whereas administration of rhubarb enema to 5/6Nx rats decreased serum levels of IS, renal oxidative stress, and NF-κB levels.
Conclusion: Rhubarb enema treatment ameliorates tubulointerstitial fibrosis in the kidneys of 5/6Nx rats, most likely by alleviating IS overload and reducing kidney oxidative stress and inflammatory injury.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684395 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144726 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Article Synopsis
- - Minimal hepatic encephalopathy (MHE) is an early and often overlooked stage of hepatic encephalopathy that requires prompt diagnosis and treatment to improve patient outcomes.
- - A study revealed that rhubarb decoction (RD), through a retention enema, enhanced liver function, reduced blood ammonia, eased brain swelling, and improved cognitive abilities in rats with MHE while positively impacting gut bacteria and bile acid metabolism.
- - The research suggests that the enterohepatic circulation of bile acids plays a crucial role in the cognitive improvements seen with RD treatment, paving the way for further studies and potential clinical applications of this herbal remedy.
Efficacy of Qifu Lizhong enema prescription on intestinal mucosal tight junction function modulation of ulcerative colitis rat model.
J Tradit Chin Med
April 2023
Clinical Medical college, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
Objective: To investigate the efficacy and mechanism of Qifu Lizhong enema prescription(, QFLZ) on intervening ulcerative colitis (UC) rat model with TCM spleen and kidney insufficiency syndrome.
Methods: Seventy-two male Sprague-Dawley rats were randomly assigned to six groups: normal model, mesalazine, and QFLZ high, medium, and low dose groups, each with 12 rats. After 3 d of adaptation feeding, all groups except the normal group were induced using rhubarb decoction in combination with trinitrobenzene sulfonic acid (TNBS)/55 % ethanol to establish a UC rat model.
Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis.
J Vis Exp
January 2023
Department of Critical Care Medicine, Hospital of Chengdu University of Traditional Chinese Medicine;
Severe acute pancreatitis (SAP) is characterized by high mortality rates, numerous complications, and extreme difficulties in treatment. A traditional Chinese medicine (TCM) enema has been widely utilized in clinical and experimental studies of SAP. It has been demonstrated to have beneficial effects in protecting pancreatic function and delaying disease progression.
View Article and Find Full Text PDFThe application of Tong-fu therapeutic method on ulcerative colitis: A systematic review and meta-analysis for efficacy and safety of rhubarb-based therapy.
Front Pharmacol
October 2022
School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
: Tong-fu therapeutic method (TFTM) is a traditional Chinese medicine treatment method for ulcerative colitis, which is a novel treatment strategies and have purgative effect. As the most representative medicinal of TFTM, Rhubarb has been reported to have a therapeutic impact on ulcerative colitis by regulating intestinal flora, anti-inflammation, and improving intestinal microcirculation. Although rhubarb has been widely used in Chinese medicine for the treatment of ulcerative colitis, the appropriate protocol is still demanded to its rational use in clinic, which promoted to evaluate the efficacy and safety for rhubarb-based therapy on ulcerative colitis.
View Article and Find Full Text PDFDeoxycholic acid-chitosan coated liposomes combined with in situ colonic gel enhances renal fibrosis therapy of emodin.
Phytomedicine
July 2022
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 311402, China. Electronic address:
Background: Renal fibrosis is the final common pathological feature of various chronic kidney diseases (CKD). Despite recent advances, development of new treatments strategy is needed. Emodin (EMO), an important ingredient of Chinese medicine, rhubarb (Polygonaceae Rheum palmatum l.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!