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Childhood-onset systemic lupus erythematosus: A descriptive and comparative study of clinical, laboratory, and treatment characteristics in two populations.
Lupus
September 2024
Division of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Objective: The aim of this study was to characterize childhood-onset systemic lupus erythematosus (SLE) in two large cohorts from Turkey and the United States.
Methods: Patients diagnosed with childhood-onset SLE who fulfilled the 1997 American College of Rheumatology classification criteria for SLE from four reference centers in Turkey and the University of Pittsburgh School of Medicine in the United States were included in this study. A comparative analysis was conducted to evaluate the similarities and differences in clinical and laboratory features, damage accrual, and treatment experiences between the two populations.
Body mass index does not affect response of rituximab in patients with rheumatoid arthritis: results from the TURKBİO registry.
Turk J Med Sci
May 2024
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkiye.
Background/aim: Adipose tissue produces several inflammatory mediators. Thus, obesity affects the disease course and the responses to the antirheumatic agents in inflammatory diseases. The aim of the study was to determine whether the body mass index (BMI) is involved in the response to rituximab in rheumatoid arthritis (RA).
View Article and Find Full Text PDFUnveiling cancer risk in ANCA-associated vasculitis: result from the Turkish Vasculitis Study Group (TRVaS).
Intern Emerg Med
June 2024
Faculty of Medicine, Division of Rheumatology, Hacettepe University, Ankara, Turkey.
Article Synopsis
- A study examined cancer rates in patients with ANCA-associated vasculitis (AAV) by comparing them to cancer risks in the Turkish population and identifying independent risk factors.
- Of the 461 AAV patients tracked, 19 developed cancer after an average follow-up of about 3.4 years, with higher cancer risks noted in older males and those with anti-PR3-ANCA positivity.
- The overall cancer risk for AAV patients was 2.1 times higher than that of the general population, highlighting the need for targeted cancer screening, especially for lung and head-neck cancers in older male patients.
Management of Adult Primary Immune Thrombocytopenia: Delphi-Based Consensus Recommendations.
Turk J Haematol
May 2024
Abdi İbrahim İlaç Sanayi ve Tic. A.Ş., Senior Medical Manager, İstanbul, Türkiye
Objective: Primary immune thrombocytopenia (pITP) is an acquired autoimmune disorder related to the increased destruction and/or impaired production of platelets. Its diagnosis and management are challenging and require expertise and the interpretation of international consensus reports and guidelines with national variations in availability. We aimed to assess the agreement of hematologists in Türkiye on certain aspects of both first-line and second-line management of patients with pITP.
View Article and Find Full Text PDFAnalysis of clinical, immunological characteristics, damage, and survival in 300 Turkish systemic lupus erythematosus patients.
Lupus
March 2024
Department of Rheumatology, Internal Medicine, Kocaeli University, Kocaeli, Turkey.
Objective: This retrospective study aimed to conduct a comprehensive analysis of Turkish Systemic Lupus Erythematosus (SLE) patients of Caucasian ethnicity, focusing on their clinical, immunological, and therapeutic characteristics, damage accural and mortality.
Patients And Methods: We carried out a retrospective assessment of 300 SLE patients diagnosed between 2001 and 2017 at Kocaeli University Rheumatology Clinic. Demographic data, clinical manifestations, immunological profiles, treatment approaches, disease-related damage, and survival information were collected.
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