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17β-Estradiol (E2) Activates Matrix Mineralization through Genomic/Nongenomic Pathways in MC3T3-E1 Cells.
Int J Mol Sci
April 2024
Department of Integrative Physiology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, Japan.
Article Synopsis
- * Treatment with E2 enhances matrix mineralization but is inhibited by certain antagonists of estrogen receptors, indicating a complex interaction at play.
- * The study reveals that E2 activates the p38 MAPK pathway through estrogen receptors, potentially leading to the release of signaling molecules that could provide targets for osteoporosis treatments.
BRAFV600E Mutation Enhances Estrogen-Induced Metastatic Potential of Thyroid Cancer by Regulating the Expression of Estrogen Receptors.
Endocrinol Metab (Seoul)
December 2022
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Backgruound: Cross-talk between mitogen-activated protein kinase and estrogen has been reported; however, the role of BRAFV600E in the estrogen responsiveness of thyroid cancer is unknown. We elucidated the effect of BRAFV600E on the estrogen-induced increase in metastatic potential in thyroid cancer.
Methods: Using a pair of cell lines, human thyroid cell lines which harbor wild type BRAF gene (Nthy/WT) and Nthy/BRAFV600E (Nthy/V600E), the expression of estrogen receptors (ERs) and estrogen-induced metastatic phenotypes were evaluated.
Sex differences in the participation of endothelial mediators and signaling pathways involved in the vasodilator effect of a selective GPER agonist in resistance arteries of gonadectomized Wistar rats.
Life Sci
November 2022
Department of Physiological Sciences, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil. Electronic address:
Aim: Endothelial mechanisms underlying the vascular effects of estrogen modulated by the G protein-coupled estrogen receptor (GPER) are not well understood, especially in gonadal sex hormone deprivation. Thus, we investigated vascular function and endothelial signaling pathways involved in the selective activation of GPER in resistance arteries of gonadectomized rats.
Methods: Gonadectomy was performed in Wistar rats of both sexes.
Estrogen receptor variant ER-α36 facilitates estrogen signaling via EGFR in glioblastoma.
Cell Biol Int
November 2022
College of Life Science, Liaoning Normal University, Dalian, Liaoning, China.
Glioblastoma (GBM) is a deadly and common primary brain tumor. Poor prognosis is linked to high proliferation and cell heterogeneity. Sex differences may play a role in patient outcome.
View Article and Find Full Text PDFG protein-coupled receptor 30 mediates cell proliferation of goat mammary epithelial cells via MEK/ERK&PI3K/AKT signaling pathway.
Cell Cycle
October 2022
Key Laboratory of Animal Biotechnology, Ministry of Agriculture, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
The mammary gland of mammals possesses the specific function of synthesizing, secreting, and delivering milk. Notably, mammary epithelial cells are considered to be central to control the expansion and remodeling of mammary gland into a milk-secretory organ. And the biological function of mammary gland is mainly regulated by the endocrine system, especially for estrogen.
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