The first occurrence of an acetylenic 1-amino-2-alcohol, distaminolyne A (1), isolated from the New Zealand ascidian Pseudodistoma opacum, is reported. The isolation and structure elucidation of 1 and assignment of absolute configuration using the exciton coupled circular dichroism technique are described. In addition, a new N-9 hydroxy analogue (2) of the known P. opacum metabolite 7-bromohomotrypargine is also reported. Antimicrobial screening identified modest activity of 1 toward Escherichia coli, Staphylococcus aureus, and Mycobacterim tuberculosis, while 2 exhibited a moderate antimalarial activity (IC50 3.82 μM) toward a chloroquine-resistant strain (FcB1) of Plasmodium falciparum.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jnatprod.5b00770 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Impact of the COVID-19 Pandemic on Tele-ophthalmology-Based Retinal Screening.
Ophthalmol Ther
September 2024
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Introduction: This study reports our experiences with systematic retinal screening in Denmark through optometrists with access to tele-ophthalmological services before, during, and after the COVID-19 pandemic.
Methods: We evaluated an optometrist-based retinal screening system with a referral option for tele-ophthalmological service by a consultant ophthalmologist within the time period of August 1, 2018 to September 30, 2023. The optometrist collected patient history, refraction, best-corrected visual acuity, intraocular pressure, basic slit-lamp examination, 4-in-1 visual field report, and retinal imaging using color fundus 45° photography.
Drop it all: extraction-free detection of targeted marine species through optimized direct droplet digital PCR.
PeerJ
February 2024
Biosecurity Group, Cawthron Institute, Nelson, New Zealand.
Article Synopsis
- Molecular biomonitoring is increasingly using environmental DNA (eDNA) to detect marine non-indigenous and endangered species, but current methods are time-consuming and hinder management efforts.
- A new direct droplet digital PCR (direct-ddPCR) technique allows for the detection of species-specific free-floating eDNA in seawater without filtration or extraction.
- An aquarium study showed that eDNA signals from targeted marine species can be consistently detected, with lifespan and detectability influenced by factors like organism biomass and species characteristics, suggesting potential for rapid monitoring and management applications.
Genome-wide analysis of early vascular tunic repair and regeneration for Botrylloides digenesis reveals striking similarities to human wound healing.
Dev Biol
May 2024
Developmental Genomics Laboratory, Department of Anatomy, School of Biomedical Sciences, University of Otago, PO Box 56, Dunedin, 9054, New Zealand. Electronic address:
The early stages of regeneration after injury are similar to those of wound healing. The ascidian Botrylloides diegensis can regenerate an entire adult from a small fragment of vascular tunic following the removal of all zooids in an injury-induced regeneration model. We investigated the molecular and cellular changes following injury to determine the differences between the healing process and the initiation of whole-body regeneration (WBR).
View Article and Find Full Text PDFThe molecular basis of ascidian whole body regeneration.
Genesis
November 2023
Department of Anatomy, University of Otago, Dunedin, New Zealand.
Prokaryotic symbiont communities in three ascidian species introduced in both Ireland and New Zealand.
Environ Sci Pollut Res Int
January 2023
Department of Biology & Marine Biology, and Center for Marine Science, University of North Carolina Wilmington, 5600 Marvin K. Moss Lane, Wilmington, NC, 28409, USA.
Ascidians or sea squirts are among the marine taxa with the most introduced species worldwide. These animals have a suite of biological characteristics that contribute to their successful establishment, including long reproductive seasons, rapid growth rates, and resistance to pollution. Here, we sequenced a fragment of the 16S ribosomal RNA gene to characterize symbiont diversity and host-specificity in the solitary species Syela clava and Ascidiella aspersa, and the colonial species Didemnum vexillum.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!