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Pericytes in Glioblastoma: Hidden Regulators of Tumor Vasculature and Therapy Resistance.
Cancers (Basel)
December 2024
Research Group on Tumors of the Central Nervous System, Pathology Department, University of Valencia, 46010 Valencia, Spain.
Glioblastoma IDH wild type (GB), the most common malignant primary brain tumor, is characterized by rapid proliferation, extensive infiltration into surrounding brain tissue, and significant resistance to current therapies. Median survival is only 15 months despite extensive clinical efforts. The tumor microenvironment (TME) in GB is highly specialized, supporting the tumor's aggressive behavior and its ability to evade conventional treatments.
View Article and Find Full Text PDFPeutz-Jeghers syndrome - Be in need of vigilance: A case report.
J Family Med Prim Care
December 2024
Department of Surgery, Datta Meghe Medical College, DMIHER University, Wardha, Maharashtra, India.
Peutz-Jeghar syndrome (PJS) is an inherited condition that puts people at an increased risk for developing hamarotmatous polyps in the digestive tract as well as cancers of the breast, colon, rectum, pancreas, stomach, testicles, ovaries, lung and cervix. With typical presentation, majority cases of PJS can be diagnosed in childhood. PJS is inherited by mutation in the STK II gene, also known as LKB1 gene.
View Article and Find Full Text PDFManagement of pediatric Peutz-Jeghers syndrome: Highlighting the efficacy and safety of endoscopic ischemic polypectomy.
J Pediatr Gastroenterol Nutr
January 2025
Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Objectives: Patients with Peutz-Jeghers syndrome (PJS) require continuous medical management throughout their lives. However, few case series regarding the clinical course, polyp surveillance, and treatment, including endoscopic ischemic polypectomy (EIP) for pediatric patients with PJS, were reported. We analyzed the current status and clinical course of pediatric patients with PJS under the management of our institute, including those treated with EIP.
View Article and Find Full Text PDFIntussusception, a condition in which one part of the intestine telescopes into another, primarily affects children under 18 months of age. This case report details the radiologic findings in a six-year-old child with a long-standing history of recurrent ileocolic intussusception, who presented with abdominal pain and was diagnosed with intussusception-associated appendicitis. Following the fifth recurrence, the patient underwent laparoscopic reduction of the intussusception and appendectomy.
View Article and Find Full Text PDFClinical and Radiological Factors Associated with Nonoperative Management Failure for Small Bowel Obstruction: A Retrospective Study from a Resource-Limited Setting.
Ther Clin Risk Manag
December 2024
Department of General Surgery, School of Medicine, Ibb University, Ibb, Yemen.
Background: Recognizing factors that predict non-operative management (NOM) failure for patients with small bowel obstruction (SBO) aids in limiting surgical intervention when needed. This study investigated the predictive factors for NOM failure in SBO patients in a resource-limited setting.
Material And Method: A retrospective study included 165 patients who were diagnosed with SBO and were admitted and managed at Althora General Hospital, IBB, Yemen, from April 2022 to March 2024.
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