AI Article Synopsis
- Klotho is an anti-aging gene influenced by various factors, with some like calcitonin gene-related peptide and fibroblast growth factor 2 boosting its expression, while others like the renin-angiotensin system and oxidative stress diminish it.
- There are two types of Klotho proteins: membrane-bound and secreted, both of which play critical roles in bodily functions.
- Klotho is linked to numerous diseases, including vascular calcification, atherosclerosis, hypertension, and diabetes, making its regulation and role in these diseases significant for medical research.
Article Abstract
Klotho, a newly identified anti-aging gene, can be regulated by many factors, such as calcitonin gene-related peptide, fibroblast growth factor 2 could up-regulate Klotho expression; whereas renin-angiotensin system, urinary toxins, inflammation and oxidative stress could reduce expression of Klotho. There are two forms of Klotho protein: membrane-bound Klotho and secreted Klotho. Existing studies showed that Klotho was involved in the development of many diseases, including vascular calcification, atherosclerosis, hypertension, kidney damage, hyperparathyroidism, diabetes and tumors. In this paper, the regulation of Klotho expression and its role in diseases are reviewed briefly.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!