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Photochemical Hydroxyl Group Abstraction from -Hydroxypyridine-2(1)-thione Isolated in a Solid Hydrogen Matrix: Photogeneration of 2-Mercaptopyridine.
Molecules
November 2024
Institute of Physics, Polish Academy of Sciences, Al. Lotnikow 32/46, 02-668 Warsaw, Poland.
Monomers of -hydroxypyridine-2(1)-thione were isolated in low-temperature matrices of solid normal hydrogen (n-H). The matrix-isolated compound was irradiated with UV-B (λ = 305 nm) or UV-A (λ > 360 nm) light. Upon such irradiation, the initial form of -hydroxypyridine-2(1)-thione was completely consumed and converted into photoproducts.
View Article and Find Full Text PDFQuantitative analysis of patient motion in walk-through PET scanner and standard axial field of view pet scanner using infrared-based tracking.
EJNMMI Phys
November 2024
Department of Electronics and Information Systems, Medical Image and Signal Processing, Ghent University, C. Heymanslaan 10, Ghent, Belgium.
Background: Long-axial field-of-view (LAFOV) Positron Emission Tomography (PET) scanners provide high sensitivity, but throughput is limited because of time-consuming patient positioning. To enhance throughput, a novel Walk-Through PET (WT-PET) scanner has been developed, allowing patients to stand upright, supported by an adjustable headrest and hand supports. This study evaluates the degree of motion in the WT-PET system and compares it with the standard PET-CT.
View Article and Find Full Text PDFSSA-ZP on Scalp Seborrheic Dermatitis: Regulating Sebum Levels and Scalp Barrier.
J Cosmet Dermatol
October 2024
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Background: The occurrence of scalp seborrheic dermatitis (SD) is closely related to the production of sebum and scalp barrier function. Supramolecular salicylic acid has the keratolytic and anti-inflammatory properties, and zinc pyrithione is an antifungal drug delivered as a microparticle to skin epithelia.
Objective: This study aimed to assess the efficacy and safety of 2% supramolecular salicylic acid (SSA) combined with 0.
A New Purpose to Old Arsenal: Exploring the Safety and Efficacy of a New Regimen Comprising a Combination of Chlorhexidine Gluconate and Cetrimide for Seborrheic Dermatitis Treatment in a Randomized Placebo-Controlled Clinical Trial.
Cureus
September 2024
Savlon Swasth India Mission, ITC Life Sciences and Technology Centre, Bangalore, IND.
Background: Seborrheic dermatitis is a common scalp condition affecting the quality of life of individuals across all age groups. The uninhibited proliferation of and enhanced sebaceous gland activity often leads to scalp flaking, mild erythema, and itching, thereby worsening the situation. Here, we aimed to study the efficacy of an antiseptic liquid as a pre-shampoo rinse followed by a non-anti-dandruff shampoo as a dandruff care strategy.
View Article and Find Full Text PDFLanthanide conjugate Pr-MPO elicits anti-cancer activity by targeting lysosomal machinery and inducing zinc-dependent cataplerosis.
Cell Commun Signal
October 2024
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, 117597, Singapore.
Acquired drug resistance is a major challenge in the management of cancer, which underscores the need for discovery and development of novel therapeutic strategies. We report here the mechanism of the anti-cancer activity of a small coordinate complex composed of the rare earth metal praseodymium (Pr) and mercaptopyridine oxide (MPO; pyrithione). Exposure of cancer cells to relatively low concentrations of the conjugate Pr-MPO (5 µM) significantly impairs cell survival in a p53-independent manner and irrespective of the drug resistant phenotype.
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