AI Article Synopsis
- This study integrated chemistry, biology, and pharmacology to identify pseudoallergenic substances in Shuang-huanglian injection (SHLI), aiming to create a systematic screening method for traditional Chinese medicine injections.
- Using mouse models, researchers tested SHLI's intermediate extracts, finding that Forsythia suspensa had the strongest pseudoallergic reaction, primarily due to its larger chemical polarity.
- The study pinpointed forsythiaside A and arctiin as key components causing these reactions, and removing forsythiaside A using HPLC-MS significantly improved SHLI's safety, offering a foundation for future research on pseudoallergic substances in other traditional Chinese medicine injections.
Article Abstract
In this study, chemistry, biology and pharmacology were combinated to screen pseudoallergenic substances of Shuang-huanglian injection (SHLI) so that to establish a scientific and systematic approach to screen pseudoallergenic substances of traditional Chinese medicine injections. The mouse pseudoallergic reaction models were used to screen the pseudoallergic reaction of SHLI's intermediate extract and the intermediate extract's component or ingredient. Among the three intermediates of Shuanghuanglian injection (extract of Scutellaria baicalensis, extract of Lonicera japonica, extract of Forsythia suspensa) , pseudoallergic action of Forsythia suspensa was the strongest, Forsythia suspesnsa's pseudoallergic reaction mainly associated with the composition with largerchemical polarity. Further it was found that forsythiaside A and arctiin which existed in the the composition with largerchemical polarity caused obvious pseudoallergic reactions. SHLI with removal forsythoside A with the technology of HPLC-MS displayed reduced pseudoallergic reaction and a significant improved safety. This study provided a scientific basis for SHLI process improvements and also offered idea and research foundation for screening pseudoallergenic substances injections in other TCM injections.
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