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Alzheimer's Genetic Risk Intensifies Neurocognitive Slowing Associated with Diabetes in Non-Demented Older Adults. | LitMetric
Introduction : We examine interactive and intensification effects of type 2 diabetes (T2D) with and an Alzheimer's disease Genetic Risk Score (GRS) on neurocognitive speed performance and change in non-demented older adults.Methods : In an accelerated longitudinal design, we used latent growth modeling to test moderators of level and change in a neurocognitive speed latent variable for 628 adults (baseline age=69.0) followed over 9 years. The GRS was compiled using the cumulative risk of , , and .Results : First, T2D predicted slower speed performance at centering age (75). Second, no predictive effects were associated with or GRS. Third, a significant interaction showed that high risk from both T2D and GRS was selectively associated with steeper longitudinal slowing than all comparison cross-domain risk groups.Discussion : Higher AD-related genetic risk intensified deleterious effects of diabetes on neurocognitive slowing in non-demented aging beyond the independent influence of .
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