Phenytoin-induced acute hypersensitivity pneumonitis.

Lung India

Metro Centre for Respiratory Diseases, Metro Hospitals and Heart Institute, Noida, Uttar Pradesh, India.

Published: December 2015

Lungs are target organs for toxic effects of various drugs due to many reasons. Diphenylhydantoin (DPH) is reported to have many extrapulmonary side effects. We are presenting a case of acute hypersensitivity pneumonitis (HP) secondary to DPH, presenting with respiratory failure. Acute HP with respiratory failure is an uncommon drug side effect of the DPH therapy and is a diagnosis of exclusion. It requires detailed workup and exclusion of other causes along with evidence of improvement in the patient's condition after withholding DPH.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663873PMC
http://dx.doi.org/10.4103/0970-2113.168126DOI Listing

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