Objective: Airway resistance is the mechanical cause of most of the symptoms in obstructive pulmonary disease, and can be considered as the primary measure of disease severity. A low-cost and noninvasive method to measure the airway resistance that does not require patient effort could be of great benefit in evaluating the severity of lung diseases, especially in patient population that are unable to use spirometry, such as young children.
Methods: The Vision-Based Passive Airway Resistance Estimation (VB-PARE) technology is a passive method to measure airway resistance noninvasively. The airway resistance is estimated from: 1) airflow extracted from processing depth data captured by a Microsoft Kinect, and 2) Pulsus Paradoxus extracted from a pulse oximeter (SpO ).
Results: To verify the validity and accuracy of the VB-PARE, two phases of experiment were conducted. In Phase I, spontaneous breathing data was collected from 14 healthy participants with externally induced airway obstruction, and the accuracy of 76.2±13.8% was achieved in predicting three levels of obstruction severity. In Phase II, VB-PARE outputs were compared with the clinical results from 14 patients. VB-PARE estimated the tidal volume with an average error of 0.07±0.06 liter. Also, patients with airway obstruction were detected with 80% accuracy.
Conclusion: Using the information extracted from Kinect and SpO , here, we present a quantitative method to measure the severity of airway obstruction without requiring active patient involvement.
Significance: The proposed VB-PARE system contributes to the state-of-art respiration monitoring methods by expanding the idea of passive and noninvasive airway resistance measurement.
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http://dx.doi.org/10.1109/TBME.2015.2505732 | DOI Listing |
Rationale: Airflow obstruction refractory to β2 adrenergic receptor (β2AR) agonists is an important clinical feature of infant respiratory syncytial virus (RSV) bronchiolitis, with limited treatment options. This resistance is often linked to poor drug delivery and potential viral infection of airway smooth muscle cells (ASMCs). Whether RSV inflammation causes β2AR desensitization in infant ASMCs is unknown.
View Article and Find Full Text PDFCureus
December 2024
Department of Anaesthesiology, Seirei Hamamatsu General Hospital, Hamamatsu, JPN.
One-lung ventilation is commonly used in lateral open chest surgery; however, it can increase pulmonary vascular resistance, which negatively affects Fontan circulation. Nevertheless, one-lung ventilation has a positive indication in post-Fontan patients. It allows surgery with lateral minimally invasive thoracotomy, which does not require a median sternotomy.
View Article and Find Full Text PDFBiofilm
June 2025
CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057, Braga, Portugal.
Antibiotics are central to managing airway infections in cystic fibrosis (CF), yet current treatments often fail due to the presence of biofilms, settling down the need for seeking therapies targeting biofilms. This study aimed to investigate the antibiofilm activity of aspartic acid and its potential as an adjuvant to tobramycin against biofilms formed by mucoid and small colony variant (SCV) tobramycin tolerant strain. We assessed the effect of aspartic acid on both surface-attached and suspended biofilms within CF artificial mucus and investigated the synergistic impact of combining it with non-lethal tobramycin concentrations.
View Article and Find Full Text PDFChildren (Basel)
January 2025
Department of Otorhinolaryngology, University Hospital "St. George" Plovdiv, 4000 Plovdiv, Bulgaria.
Background: Foreign body aspiration is a preventable occurrence that carries a high risk of mortality in the pediatric population. Clinically, foreign body aspiration manifests as cough, followed by choking, which might not be given any consideration by the caregivers of the child. An episode of sudden wheezing can also raise the suspicion of a foreign body in the lower respiratory tract.
View Article and Find Full Text PDFAerosp Med Hum Perform
January 2025
Introduction: The introduction of fifth-generation fighter aircraft has raised concerns regarding the impact of high gravitational forces on lung function. This study aimed to investigate the acute effects of controlled +Gz exposure, up to +9 Gz, on lung function in military pilots using impulse oscillometry (IOS).
Methods: These studies, conducted in Canada and the Netherlands, involved military pilots undergoing high G centrifuge training.
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