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Dexmedetomidine in the Treatment of Depression: An Up-to-date Narrative Review.
Clin Pract Epidemiol Ment Health
August 2023
Department of Psychiatry and Centre for Neuroscience Studies, Queens University, Kingston, Canada.
Depressive disorders (DD) are common, and their prevalence is expected to rise over the next decade. Depressive disorders are linked to significant morbidity and mortality. The clinical conundrum of depressive disorders lies in the heterogeneity of their phenomenology and etiology.
View Article and Find Full Text PDFOral ketamine may offer a solution to the ketamine conundrum.
Psychopharmacology (Berl)
December 2023
Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia.
Ketamine has received considerable attention for its rapid and robust antidepressant response over the past decade. Current evidence, in clinical populations, predominantly relates to parenterally administered ketamine, which is reported to produce significant undesirable side effects, with additional concerns regarding long-term safety and abuse potential. Attempts to produce a similar drug to ketamine, without the psychotomimetic side effects, have proved elusive.
View Article and Find Full Text PDFDiagnosing the Dermatologic Blues: Systematic Review of the Rare Conundrum, Psychogenic Purpura.
JMIR Dermatol
September 2023
Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Background: Psychogenic purpura is an idiopathic psychodermatologic condition of recurrent, painful purpura precipitated by psychological stress, predominantly affecting young females. Little consensus exists on the diagnostic guidelines for this rare condition, often resulting in costly, unnecessary, and stressful investigations as well as prolonged hospital admissions.
Objective: With this first up-to-date systematic review of 134 cases of psychogenic purpura in over a decade, we aim to thoroughly investigate the diagnostic strategy and treatment regimens used in the last decade.
The conundrum of antidepressant use in bipolar disorder.
Mol Psychiatry
March 2023
Translational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences at McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.
Bipolar depression: a review of treatment options.
Gen Psychiatr
August 2022
Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Bipolar depression (BD-D) is both common and incredibly challenging to treat. Even treated individuals with BD-D experience depression approximately 19% of the time, and subsyndromal depression an additional 18%. This stands in clear contrast to the approximately 10% of time spent in hypomania and 1% of time spent in mania.
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