AI Article Synopsis
- * While the response to hydrogen peroxide (H2O2) differs based on chemotype, both strains show increased production of trichothecene B toxins when exposed to diamide, indicating Fgap1’s regulatory role.
- * The NIV/FX chemotype has greater antioxidant defenses but still accumulates more toxins under extreme oxidative stress scenarios, like heightened H2O2 levels.
Article Abstract
This study aims to compare the role of the transcription factor Fgap1 in oxidative stress response for two Fusarium graminearum strains belonging to the two chemotypes DON/ADON and NIV/FX. While the response to H2O2 was shown to be chemotype dependent, an opposite result was observed for diamide: whatever the chemotype, the global level of TCTB (i.e. trichothecene B) production was strongly increased by the treatment with diamide. Fgap1 was shown to be involved in this regulation for both chemotypes. Our data show that the response to diamide is mediated by Fgap1 whatever the chemotype of the F. graminearum strains. However, the NIV/FX chemotype has developed higher antioxidant capacities in response to oxidative stress. But when this capacity is overwhelmed by an increment in the H2O2 level, the NIV/FX strains also responds by an increase in toxin accumulation.
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| http://dx.doi.org/10.1093/femsle/fnv232 | DOI Listing |
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