Globally, maternal and fetal health is greatly impacted by extraplacental inflammation. Group B Streptococcus (GBS), a leading cause of chorioamnionitis, is thought to take advantage of the uterine environment during pregnancy in order to cause inflammation and infection. In this study, we demonstrate the metabolic changes of murine macrophages caused by GBS exposure. GBS alone prompted a delayed increase in lactate production, highlighting its ability to redirect macrophage metabolism from aerobic to anaerobic respiration. This production of lactate is thought to aid in the development and propagation of GBS throughout the surrounding tissue. Additionally, this study shows that PGE2 priming was able to exacerbate lactate production, shown by the rapid and substantial lactate increases seen upon GBS exposure. These data provide a novel model to study the role of GBS exposure to macrophages with and without PGE2 priming.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.chemrestox.5b00322 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exposure to Group B Streptococcus-induced chorioamnionitis alters the proteome of placental extracellular vesicles.
Placenta
January 2025
Department of Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada. Electronic address:
Introduction: Group B Streptococcus (GBS) is an opportunistic pathogen that can induce chorioamnionitis (CA), increasing the risk of neurodevelopmental disorders (NDDs) in the offspring. The placenta facilitates maternal-fetal communication through the release of extracellular vesicles (EVs), which may carry inflammatory molecules such as interleukin (IL)-1. Although the role of EVs in immune modulation is well established, their specific characterization in the context of GBS-induced CA has not yet been investigated.
View Article and Find Full Text PDFMaternal group B decreases infant length and alters the early-life microbiome: a prospective cohort study.
Ann Med
December 2025
Department of Laboratory Medicine, Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Background: Maternal colonization with Group B Streptococcus (GBS) disrupts the vaginal microbiota, potentially affecting infant microbiota assembly and growth. While the gut microbiota's importance in infant growth is recognized, the specific effects of maternal GBS on growth remain unclear. This study aimed to explore the effects of maternal vaginal GBS during pregnancy on early infant growth, microbiome, and metabolomics.
View Article and Find Full Text PDFIL-1 Blockade Mitigates Autism and Cerebral Palsy Traits in Offspring In-Utero Exposed to Group B Chorioamnionitis.
Int J Mol Sci
October 2024
Department of Pediatrics, Research Institute of the McGill University Health Centre, McGill University, 1001 Decarie Boulevard, Montreal, QC H4A 3J1, Canada.
Group B (GBS) is one of the most common bacteria responsible for placental and neonatal infection and inflammation resulting in lifelong neurobehavioral impairments. In particular, GBS-induced chorioamnionitis is known in preclinical models to upregulate inflammatory pathways, primarily through the activation of the interleukin-1 (IL-1) pathway, leading to brain injury and subsequent neurodevelopmental issues. Previous studies from our laboratory using Lewis rat pups have shown that male offspring exposed in utero to GBS chorioamnionitis develop brain injuries leading to neurobehavioral impairments such as autistic traits.
View Article and Find Full Text PDFPrevalence and Mortality of Pediatrics with Guillain-Barré Syndrome during the COVID-19 Pandemic and Pre-COVID-19 Periods.
Iran J Child Neurol
September 2024
Pediatric Neurology Department, Mofid Children's Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- * Researchers analyzed data from Iranian hospitals, finding a total of 1,282 registered GBS cases (778 pre-COVID vs. 504 during COVID), indicating a decrease in diagnoses during the pandemic.
- * The study concluded that while GBS cases dropped during COVID-19, there were no significant changes in demographic characteristics, clinical outcomes, or mortality rates between the two periods.
Mechanical ventilation, hospitalization time, deaths and disability according to the variants of Guillain-Barré syndrome: systematic review and meta-analysis.
Rev Peru Med Exp Salud Publica
October 2024
Universidad Peruana de Ciencias Aplicadas, Lima, Perú.
Background: Motivation for the study. It is unclear which variant of Guillain-Barré syndrome is mostly associated with adverse outcomes.
Background: Main findings.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!