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ROS scavenging and corneal epithelial wound healing by a self-crosslinked tissue-adhesive hydrogel based-on dual-functionalized hyaluronic acid.
Int J Biol Macromol
December 2024
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China; State Key Laboratory of Ophthalmology, Optometry and Vision Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China. Electronic address:
Reactive oxygen species (ROS) scavenging is a viable approach to promote corneal epithelium wound healing. This study created a single-component hydrogel (HA Gel) with a novel dual-functionalized hyaluronic acid derivative (HA-GA-PBA) containing gallol and phenylboronic acid (PBA) moieties. Both of these moieties were dual-functional.
View Article and Find Full Text PDFTherapeutic Effects of Human Placental Extracts Eye Drops in Experimental Dry Eye and Alkali Burn.
J Ocul Pharmacol Ther
December 2024
Department of Ophthalmology, Chonnam National University Medical School and Hospital, Gwangju, Korea.
To evaluate the efficacy of human placental extract (HPE) eye drops compared to that of carboxymethylcellulose (CMC) and human peripheral blood serum (HPBS) eye drops in a mouse model of experimental dry eye (EDE) and corneal alkali burns. EDE and alkali burn models were induced in C57BL/6 mice using desiccating stress and NaOH, respectively. In both the EDE and alkali burn models, treatment groups received CMC, HPBS, or HPE eye drops.
View Article and Find Full Text PDFCorneal protein repair after amniotic membrane photo-tissue bonding versus amniotic membrane graft in the treatment of corneal ulcer (an experimental study).
Sci Rep
December 2024
Department of Medical Application of Laser, Ophthalmic Unit, National Institute of Laser Enhanced Sciences, Cairo University, Giza, Egypt.
Corneal alkali burns persist as a significant challenge in our field, often leading to a prolonged treatment course with various sight-threatening problems. This work, of utmost importance, aimed to apply the photo-tissue bonding technique (PTB) to weld the amniotic membrane (AM) to the corneal surface versus an amniotic membrane graft (AMG) and explore its safety in saving corneal protein against alkali burn.Methods Twenty-seven rabbits with an induced corneal ulcer using 1 mol/L NaOH solution.
View Article and Find Full Text PDFAutologous simple limbal stem cell transplantation with conjunctival autograft in chronic unilateral total LSCD with severe symblepharon due to severe alkali burn.
BMJ Case Rep
December 2024
Department of Ophthalmology, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India.
This report details the case of a middle-aged man with chronic unilateral total limbal stem cell deficiency with severe symblepharon in his left eye with upper lid mechanical ptosis, restricted ocular movements and visual acuity limited to counting fingers at 2 feet. 9 months prior to his first visit, he sustained an accidental unilateral alkali injury to the left eye. He underwent autologous simple limbal epithelial transplantation combined with conjunctival autograft in the left eye.
View Article and Find Full Text PDFReconstruction of rabbit corneal epithelium using adipose and / or bone marrow stem cells.
Exp Eye Res
December 2024
Anatomy and Embryology Department, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
One of the main causes of corneal blindness is corneal alkali burn, which can also result in serious side effects such as limbal stem cell deficit, corneal perforation, and permanent epithelial abnormalities. This study set out to investigate the therapeutic potential of ADMSCs and BMMSCs for the reconstruction of the corneal surface after chemical alkali burn. Twelve adult rabbits were divided equally into four groups.
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