Terpenoids from Euphorbia pekinensis.

J Asian Nat Prod Res

a State Key Laboratory of Applied Organic Chemistry , Lanzhou University, Lanzhou 730000 , China.

Published: May 2016

Euphorpekone A (1) and euphorpekone B (2), two new diterpenoids, 3β-hydroxy-25-methyloxylanosta-8,23-diene, a new triterpenoid (3), together with a known triterpenoid, 3β,25-dihydroxylanosta-8,23-diene (4), were isolated from Euphorbia pekinensis Rupr. Their structures were elucidated on the basis of UV, IR, 1D ((1)H, (13)C, NOE) and 2D ((1)H-(1)H COSY, HSQC, HMBC) NMR, HR-ESI-MS, X-ray diffraction analysis, and CD method.

Download full-text PDF

Source
http://dx.doi.org/10.1080/10286020.2015.1118466DOI Listing

Publication Analysis

Top Keywords

euphorbia pekinensis
8
terpenoids euphorbia
4
pekinensis euphorpekone
4
euphorpekone euphorpekone
4
euphorpekone diterpenoids
4
diterpenoids 3β-hydroxy-25-methyloxylanosta-823-diene
4
3β-hydroxy-25-methyloxylanosta-823-diene triterpenoid
4
triterpenoid triterpenoid
4
triterpenoid 3β25-dihydroxylanosta-823-diene
4
3β25-dihydroxylanosta-823-diene isolated
4

Similar Publications

[Differences in toxicity and serum metabolomics of ethyl acetate fraction of Euphorbiae Pekinensis Radix before and after vinegar processing].

Zhongguo Zhong Yao Za Zhi

November 2024

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine Nanjing 210023, China.

This study aimed to investigate the toxicity differences of the ethyl acetate fraction of Euphorbiae Pekinensis Radix before and after vinegar processing and explore the detoxification mechanism of vinegar processing using non-targeted metabolomics. The changes in terpenoid components in the ethyl acetate fraction before and after vinegar processing were analyzed using UFLC-Q-TOF-MS. Normal rats were orally administered the raw and vinegar-processed ethyl acetate fractions of Euphorbia Pekinensis Radix.

View Article and Find Full Text PDF

Chloroplast genomics unravels taxonomic status and evolutionary relationships in Euphorbia fauriei and E. pekinensis.

Gene

February 2025

Department of Life Sciences, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, Republic of Korea. Electronic address:

Euphorbia fauriei, a perennial plant endemic to South Korea, exhibits both morphological characteristics and intricate genetic identities akin to E. pekinensis. This study aimed to provide clarity on the taxonomic status of E.

View Article and Find Full Text PDF

Deciphering the mechanisms underlying the neuroprotective potential of kaempferol: a comprehensive investigation.

Naunyn Schmiedebergs Arch Pharmacol

October 2024

University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India.

Neurodegenerative disorders are characterized by neuronal degradation, dysfunction, or death within the CNS. Oxidative and inflammatory stress play crucial roles in the pathogenesis of various neurodegenerative diseases. The interplay between these stressors and dysregulated cellular signaling pathways contributes to neurodegeneration.

View Article and Find Full Text PDF

Euphorbia Pekinensis Rupr. sensitizes colorectal cancer to PD-1 blockade by remodeling the tumor microenvironment and enhancing peripheral immunity.

Phytomedicine

December 2024

Wuxi Cancer Institute, Wuxi Institute of Integrated Chinese and Western Medicine, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214062, China; Laboratory of Cancer Epigenetics, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address:

Article Synopsis
  • Immune checkpoint blockade therapies, like PD-1 monoclonal antibodies, have shown promise in cancer treatment but struggle with colorectal cancer (CRC), leading researchers to explore new combination strategies, including traditional Chinese medicines.
  • The study investigated the effects of Euphorbia Pekinensis extract (EP) on CRC through various laboratory methods and animal models, assessing its potential to enhance PD-1 blockade efficacy.
  • Results revealed that EP contains key compounds, primarily diterpenoids and flavonoids, and effectively inhibited CRC cell growth by activating immune responses, suggesting it could improve treatment outcomes when combined with PD-1 therapy.
View Article and Find Full Text PDF

Rupr. roots: a comprehensive review of botany, traditional uses, phytochemistry, pharmacology, quality control, and toxicology.

Nat Prod Res

August 2024

Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming, PR China.

Rupr. is a traditional herb generally distributed in most areas of China, north Korea and Japan. The dried roots of Rupr.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!