AI Article Synopsis
- Titanium dioxide nanoparticles (TiO2 NPs) are commonly used for their bright white color and opacity, but their safety needs to be examined.
- Researchers studied the effects of anatase TiO2 NPs in Wistar rats over a 60-day period, finding significant changes in blood cell counts and shapes.
- The study revealed chromosome damage and DNA breakage in the rats, indicating potential genotoxicity at higher doses of TiO2 NPs.
Article Abstract
Titanium dioxide nanoparticles (TiO2 NPs) are widely used for their whiteness and opacity. We investigated the hematological effects and genotoxicity of anatase TiO2 NPs following sub-chronic oral gavage treatment. TiO2-NPs were characterized by X-ray diffractometry (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). Wistar rats were treated with anatase TiO2 NPs by intragastric administration for 60 days. Hematological analysis showed a significant decrease in RBC and HCT and a significant increase in MCV, PLT, MPV and WBC at higher doses. Furthermore, abnormally shaped red cells, sometimes containing micronuclei, and hyper-segmented neutrophil nuclei were observed with TiO2 NPs treatment. The micronucleus test revealed damage to chromosomes in rat bone marrow at 100 and 200mg/kg bw; the comet assay showed significant DNA damage at the same doses.
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| http://dx.doi.org/10.1016/j.mrgentox.2015.09.005 | DOI Listing |
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