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VoxRad: Building an open-source locally-hosted radiology reporting system.
Clin Imaging
January 2025
LN Medical College & JK Hospital, Kolar Road, Bhopal, Madhya Pradesh, India. Electronic address:
VoxRad is an open-source application designed to enhance radiology reporting by leveraging generative AI. Utilizing locally hosted Automatic Speech Recognition (ASR) and Large Language Models (LLM), VoxRad enables continuous dictation, transcribing reports into standardized formats with high accuracy, efficiency, and data security. The modular design allows flexible integration of user-selected ASR and LLM models via OpenAI-compatible APIs, ensuring HIPAA compliance with secure local storage of data.
View Article and Find Full Text PDFDesign and synthesis three novel series of derivatives using natural acetylcholinesterase inhibitor-RLMS as template and in vitro, in vivo and in silico activities verification.
Eur J Med Chem
January 2025
College of Chemical Engineering, Shenyang University of Chemical Technology, Shenyang, Liaoning, 110142, PR China; Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, Liaoning, 110142, PR China. Electronic address:
Acetylcholinesterase (AChE) is a pivotal enzyme in nerve conduction, controlling its activity with its inhibitor (AChEI) is crucial for the treatment of Alzheimer's disease (AD). However, current AChEIs are associated with considerable adverse effects. Previous work has identified 2α,3β,19α,23-tetrahydroxy-12-ene-28-oic acid (RLMS) as a promising natural AChEI.
View Article and Find Full Text PDFHeteroatom sulfur-doping in single-atom FeNC catalysts for durable oxygen reduction performance in zinc-air batteries.
J Colloid Interface Sci
January 2025
Department of Chemistry & Institute for Sustainable Energy, College of Sciences, Shanghai University, Shanghai 200444, PR China. Electronic address:
Heteroatom doping into the transition metal-based catalysts is an effective strategy to improve the oxygen reduction reaction (ORR) kinetics. Herein, we proposed a one-step, soft template assisted, and green method for the synthesis of Sulfur (S) doped single atom FeNC catalyst. XAFS demonstrated that the Fe active sites in the FeNSC were more likely to possess the Fe-N configuration.
View Article and Find Full Text PDFMOF-derived FeCe@Carbon catalysts for the efficient tetracycline degradation by activated persulfate: Preparation and mechanistic study.
J Colloid Interface Sci
January 2025
College of Resources and Environmental Engineering, Wuhan University of Science and Technology, Wuhan 430081 China.
Metal-organic frameworks (MOFs) derived materials are extensively utilized in wastewater treatment owing to their remarkable catalytic efficacy and durability. This study exploited iron-cerium-based bimetallic metal-organic framework (FeCe-MOF) as a sacrificial template, which was subsequently calcined at 700 °C to produce an iron-cerium-based bimetallic carbon nanospheres (FeCe@C). The FeCe@C has active sites of bimetallic Fe and Ce derivatives, demonstrating exceptional activation efficiency for persulfate, resulting in approximately 98.
View Article and Find Full Text PDFReplication across O6-methylguanine activates futile cycling of DNA mismatch repair attempts assisted by the chromatin remodeling enzyme Smarcad1.
J Biochem
January 2025
Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
SN1-type alkylating reagents generate O6-methylguanine (meG) lesions that activate the mismatch repair (MMR) response. Since post-replicative MMR specifically targets the nascent strand, meG on the template strand is refractory to rectification by MMR and, therefore, can induce non-productive MMR reactions. The cycling of futile MMR attempts is proposed to cause DNA double-strand breaks in the subsequent S phase, leading to ATR-checkpoint-mediated G2 arrest and apoptosis.
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