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The Up-to-date Treatment for Diabetes and Prevention of its Complications.
Juntendo Iji Zasshi
December 2024
Diabetes mellitus, characterized by high blood glucose due to inadequate insulin action, comprises two main types: type 1, an autoimmune disease, and type 2, marked by insulin resistance. This review provides a comprehensive overview of diabetes management and treatment advancements. Effective diabetes management includes maintaining blood glucose levels within normal ranges and monitoring HbA1c, a marker reflecting average glucose levels over the past few months.
View Article and Find Full Text PDFInsulin Delivery Pumps for Human Spaceflight: Steps Toward an Accessible Space Future.
Wilderness Environ Med
January 2025
Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA.
Commercially available insulin pumps for treatment of diabetes mellitus are currently not qualified to operate in the space environment. This work rigorously tested the fluid delivery performance of a Tandem t:slim X2 insulin pump in both micro- and hypergravity during a parabolic microgravity research flight. The parabolic research flight environment serves as an analogue to the types of transient gravitational loadings experienced during human-led missions, which provides a foundation to expand testing to suborbital and orbital flights in addition to other extreme environmental tests for wilderness dependency.
View Article and Find Full Text PDFPilot Study of a Modified DOPS Scale for Insulin Pump and CGM Installation Training in Chinese Medical Students During Endocrinology Rotations.
Diabetes Metab Syndr Obes
January 2025
Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People's Republic of China.
Background: Direct Observation of Procedural Skills (DOPS) is a clinical assessment tool that enables trainers to observe medical students' procedural abilities in real-time clinical settings. It assesses students' knowledge application, decision-making, and skill proficiency during clinical tasks.
Methods: This study modifies the DOPS to evaluate the operation of insulin pumps (PUMP) and continuous glucose monitoring systems (CGMS) in diabetes management.
L-type Calcium Channel Blockade Worsens Glucose Tolerance and β-Cell Function in C57BL6/J Mice Exposed to Intermittent Hypoxia.
Am J Physiol Endocrinol Metab
January 2025
Division of Pulmonary, Critical Care, and Sleep Medicine, University of Miami, Miller School of Medicine, Miami Florida.
Intermittent hypoxemia (IH), a pathophysiologic consequence of obstructive sleep apnea (OSA), adversely affects insulin sensitivity, insulin secretion, and glucose tolerance. Nifedipine, an L-type calcium channel blocker frequently used for treatment of hypertension, can also impair insulin sensitivity and secretion. However, the cumulative and interactive repercussions of IH and nifedipine on glucose homeostasis have not been previously investigated.
View Article and Find Full Text PDFApproach to the Patient using Diabetes Technology in Pregnancy.
J Clin Endocrinol Metab
January 2025
Section of Maternal Fetal Medicine, Obstetrics and Gynecology, University of Chicago.
Diabetes in pregnancy increases risk for complications for the pregnant patient and neonate. Tight glycemic control to maintain glucose levels as close to non-diabetic ranges as possible can lower risk for these complications. Achieving strict glycemic targets can be challenging and technologies including continuous glucose monitors (CGM) and hybrid closed loop (HCL) insulin pumps have the potential to improve diabetes control and pregnancy outcomes.
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