AI Article Synopsis
- A collaborative study was conducted to assess the repeatability and reproducibility of the AOAC First Action Method 2012.16 for measuring pantothenic acid in infant and nutritional formulas using advanced chromatography techniques.
- The study comprised two parts: qualifying labs with practice samples and then having them analyze blind duplicate samples, with the results being compared to established performance standards.
- Findings demonstrated that both repeatability (1.3-3.3%) and reproducibility (4.1-7.0%) met the required standards, leading to the method being recommended for Final Action status by the AOAC Expert Review Panel.
Article Abstract
In order to determine repeatability and reproducibility of AOAC First Action Method 2012.16 [Pantothenic Acid (Vitamin B5) in Infant Formula and Adult/Pediatric Nutritional Formula by Ultra-High Pressure Liquid Chromatography/Tandem Mass Spectrometry], a collaborative study was organized. The study was divided in two parts: method setup and qualification of participants (part 1) and collaborative study participation (part 2). For part 1, each participating laboratory was asked to analyze two practice samples using the aforementioned method. Laboratories that provided results within a range of expected levels were qualified for part 2, during which each laboratory received 10 samples in blind duplicates. Results have been compared to the Standard Method Performance Requirement (SMPR®) 2012.009 established for pantothenic acid. Precision results (repeatability and reproducibility) were within the limits stated in the SMPR. Repeatability ranged from 1.3 to 3.3%, and reproducibility ranged from 4.1 to 7.0%. Horwitz ratio (HorRat) values were all <1, ranging from 0.33 to 0.69. The AOAC Expert Review Panel on Stakeholder Panel on Infant Formula and Adult Nutritionals Nutrient Methods determined that the data presented met the SMPR and recommended the method for Final Action status, which was then granted by the AOAC Official Methods Board.
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| http://dx.doi.org/10.5740/jaoacint.15-127 | DOI Listing |
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