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Exploring the versatility of as a model organism in biomedical research: a comprehensive review.
Fly (Austin)
December 2025
College of Medicine, Faculty of Dentistry, University of Ibadan, Ibadan, Nigeria.
is a highly versatile model organism that has profoundly advanced our understanding of human diseases. With more than 60% of its genes having human homologs, provides an invaluable system for modelling a wide range of pathologies, including neurodegenerative disorders, cancer, metabolic diseases, as well as cardiac and muscular conditions. This review highlights key developments in utilizing for disease modelling, emphasizing the genetic tools that have transformed research in this field.
View Article and Find Full Text PDFCRISPR-Cas9 in basic and translational aspects of cancer therapy.
Bioimpacts
March 2024
Gene Therapy Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: The discovery of gene editing techniques has opened a new era within the field of biology and enabled scientists to manipulate nucleic acid molecules. CRISPR-Cas9 genome engineering has revolutionized this achievement by successful targeting the DNA molecule and editing its sequence. Since genomic changes are the basis of the birth and growth of many tumors, CRISPR-Cas9 method has been successfully applied to identify and manipulate the genes which are involved in initiating and driving some neoplastic processes.
View Article and Find Full Text PDFDeterminants of physical activity commitment in adolescents and young adults with cancer: sociological protocol for a hospital-based mixed methods study (ETAPE-AJA).
BMJ Open
September 2024
Department of Cancer and Environment, Léon Bérard Cancer Centre, Lyon, Rhône-Alpes, France.
Introduction: Adolescents and young adults (AYA) with cancer undergo physical transformations due to disease and treatments occurring alongside puberty and adolescence. Although physical activity is recommended for its benefits, its practice among AYA with cancer remains insufficient. The aim of the Éducation Thérapeutique et Activité Physique: Engagement des Adolescents et Jeunes Adultes atteints de cancer study is to identify the evolution of AYA with cancer medical knowledge and powers (power to act, to express oneself) over life and cancer care, and their role in commitment in adapted physical activity (APA) and therapeutic patient education during and after oncological treatments.
View Article and Find Full Text PDFUnicompartmental knee arthroplasty in octogenarians: An analysis of 1,466 patients with 2-year follow-up.
Knee
December 2024
Department of Orthopaedics, Rush University Medical Center, Chicago, IL 60612, United States. Electronic address:
Introduction: Unicompartmental knee arthroplasty (UKA) has been shown to improve pain and function in appropriately selected patients. Limited data exists regarding outcomes and complication rates following UKA among octogenarians.
Methods: The PearlDiver Mariner database was queried for patients undergoing primary UKA between 2010-2022.
Design specifications and capabilities of a 3D simulation software for clinical education of physiotherapy students in the neurology department.
BMC Med Educ
August 2024
Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
Introduction: In this revolutionized era, thanks to cutting-edge technological breakthroughs like 3-dimensional (3D) computerized environments, physiotherapy trainers can improve their knowledge and confidence by using such training tools. Hence, there is room for developing these technologies for training medical students to expand their skills and expertise. This study aims to identify the design requirements and key functionalities of a 3D simulation software for the clinical education of physiotherapy students in neurology departments.
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