AI Article Synopsis
- Prolonged antibiotic use can lead to adverse effects, including Clostridium difficile infection (CDI), and this study aimed to assess CDI incidence in patients with Crohn's disease (CD) on long-term antibiotic therapy.
- The retrospective study analyzed 100 CD patients who had been on outpatient antibiotics for over 6 months, revealing a mean treatment duration of 39.6 months and identifying fluoroquinolones and penicillins as the most commonly prescribed antibiotics.
- Results showed a CDI incidence of only 2%, which is significantly lower than incidences reported for non-CD patients on chronic antibiotics for other conditions.
Article Abstract
Background: Prolonged antibiotic use is limited by several adverse effects, one of which is Clostridium difficile infection (CDI). The aim of this study was to determine the incidence of CDI in patients receiving chronic antibiotic treatment for Crohn's disease (CD).
Methods: We conducted a retrospective review of 100 patients with CD for which ≥6 months of outpatient antibiotic therapy was prescribed. Data were collected regarding demographics, CD phenotype, treatment history, and CDI. The incidence of CDI in our patient population was calculated and compared with historical controls.
Results: 100 patients were studied-60% of men, mean age 23.9 years at CD diagnosis. Eighty-two percent had disease involving the ileum, and 33% had disease involving the colon. The mean duration of antibiotic therapy was 39.6 months (range, 6-217 months). The most commonly prescribed classes of antibiotics were fluoroquinolones (84%), penicillins (57%), and cephalosporins (32%). Forty-nine percent of patients were treated with concomitant thiopurines, 45% with budesonide, and 41% with biologics. The overall incidence of CDI was 2%. This incidence of CDI was lower than previously reported for non-CD patients receiving chronic antibiotics for continuous-flow left ventricular assist device infections (12.5%) and orthopedic prosthesis infections (22.2%).
Conclusions: The incidence of CDI is rare in patients receiving chronic antibiotic treatment for CD, and it seems significantly lower than for non-CD populations reported in the literature.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882603 | PMC |
| http://dx.doi.org/10.1097/MIB.0000000000000641 | DOI Listing |
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