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Video head impulse gain is impaired in myotonic dystrophy types 1 and 2.
Eur J Neurol
December 2024
Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Background And Purpose: This study was undertaken to examine vestibulo-ocular reflex (VOR) characteristics in myotonic dystrophy type 1 (DM1) and type 2 (DM2) using video head impulse testing (vHIT).
Methods: VOR gain, refixation saccade prevalence, first saccade amplitude, onset latency, peak velocity, and duration were compared in DM1, DM2, age-matched normal controls, and patients with peripheral and central vestibulopathies.
Results: Fifty percent of DM1 and 37.
[F]NaF PET/CT imaging of response to single fraction SABR to bone metastases from breast cancer.
Front Nucl Med
October 2023
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.
Article Synopsis
- Breast cancer often spreads to bones, and stereotactic ablative body radiation therapy (SABR) shows promise for treating this type of disease with limited metastases.
- An analysis of 14 patients who received SABR found that 15 out of 17 bone metastases had a significant reduction in [F]NaF uptake (SUV), indicating treatment effectiveness, with a median decrease of 42%.
- Meanwhile, non-tumour bone also experienced a reduction in SUV, ranging from 15% to 34%, depending on the radiation dose received.
Responses to brief perturbations of stance: EMG, midline cortical, and subcortical changes.
J Neurophysiol
September 2024
Neuroscience Research Australia, University of New South Wales, Sydney, New South Wales, Australia.
We studied simultaneous EMG and midline EEG responses, including over the cerebellum, in 10 standing subjects (35 ± 15 yr; 5 females, 5 males). Recordings were made following repeated taps to the sternum, stimuli known to evoke short-latency EMG responses in leg muscles, consistent with postural reflexes. EEG power had relatively more high-frequency components (>30 Hz) when recorded from electrodes over the cerebellum (Iz and SIz) compared with other midline electrodes.
View Article and Find Full Text PDFCase report: Down syndrome regression disorder, catatonia, and psychiatric and immunomodulatory interventions.
Front Psychiatry
July 2024
Centre for Healthy Brain Ageing, UNSW Sydney, Sydney, NSW, Australia.
Down syndrome regression disorder (DSRD) is a rare condition involving subacute cognitive decline, loss of previously acquired developmental skills, and prominent neuropsychiatric symptoms, particularly catatonia, in people with Down syndrome. It is thought to involve both autoimmune and neuropsychiatric mechanisms. Research, however, is largely restricted to case studies and retrospective case series and is particularly limited in terms of prospective longitudinal follow-up.
View Article and Find Full Text PDFThe Effect of Neoadjuvant Systemic Therapy on Surgical Outcomes After Lymph Node Dissections for Stage III Melanoma; An Australian Cohort.
Ann Surg Oncol
August 2024
Melanoma Institute Australia, The University of Sydney, Sydney, NSW, Australia.
Background: Neoadjuvant systemic therapy (NAST) for patients with stage III melanoma achieves high major pathologic response rates and high recurrence-free survival rates. This study aimed to determine how NAST with targeted therapies (TTs) and immune checkpoint inhibitors (ICIs) influences surgical outcomes after lymph node dissection in terms of complications, morbidity, and textbook outcomes.
Methods: Patients who underwent a lymph node dissection after either NAST in a clinical trial or upfront surgery for stage III melanoma between 2014 and 2022 were identified from an institutional research database.
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