Chlamydophila pneumoniae, a Gram-negative bacterium belongs to the family Chlamydiaceae, is known to cause community-acquired pneumonia and bronchitis. There is a need for genomic analyses of C. pneumoniae as its chronic infections result in reactive airway disease, lung cancer and asthma. Recent advancement in the sequencing techniques led to the generation of large genomic data. In order to utilize these data, sequence-based function predictions were used for annotating the uncharacterized genes. The genome of C. pneumoniae encodes 1052 proteins, which include a group of 366 functionally uncharacterized proteins, known as "hypothetical proteins" (HPs). Functions of these HPs were predicted by utilizing an integrated approach that combines varieties of bioinformatics tools. The functions of 142 proteins were successfully predicted and categorized into different classes of enzymes, transport proteins, binding proteins and virulence factors. Among these functionally annotated HPs, we were able to identify 12 virulent HPs. Furthermore, the HP with the highest virulence score was subjected to molecular dynamics (MD) simulations to better understand their dynamical behavior in explicit water conditions. These analyses could be utilized for an in-depth understanding of virulence mechanism. The functional knowledge of these proteins could be useful in drug design and discovery process of infections caused by C. pneumoniae.
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http://dx.doi.org/10.1007/s12539-015-0134-7 | DOI Listing |
Cureus
November 2024
Pediatric Emergency Medicine, Loma Linda University Medical Center, Loma Linda, USA.
Introduction With the COVID-19 pandemic, multiple studies described a significant drop in common respiratory viruses in children with the lockdown and restrictions. With the lifting of pandemic precautions, we had the ability to observe new patterns of respiratory illnesses in children and emergency department visits. Materials and methods We studied all respiratory nucleic acid amplification test results in emergency patients from a large metropolitan children's hospital from the years 2018 to 2023.
View Article and Find Full Text PDFNew Microbiol
November 2024
Department of Public Health and Infectious Diseases, University of Rome "Sapienza", Rome, Italy.
Chlamydia pneumoniae is the etiologic agent of respiratory tract infections in humans, including community-acquired pneumonia, and has been associated with atherosclerotic cardiovascular diseases. The present systematic review of reviews aimed at answering important questions on the involvement of C. pneumoniae in the pathogenesis of atherosclerosis, its cellular and molecular mechanisms, and whether there is evidence of a causal relationship.
View Article and Find Full Text PDFFront Cell Infect Microbiol
November 2024
The Institute of Pathogenic Biology, Hengyang Medical School, University of South China, Hengyang, China.
Jpn J Radiol
November 2024
Department of Radiology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-Machi, Yufu, Oita, 879-5593, Japan.
Purpose: To determine whether decision trees are useful for predicting organisms that cause community-acquired pneumonia (CAP).
Materials And Methods: We developed a decision tree for predicting the organisms that cause CAP based on previously reported characteristic computed tomography findings. Sixteen readers (two student doctors, six residents, and eight radiologists) separately diagnosed 68 randomly selected cases of CAP using chest computed tomography.
Rev Esp Quimioter
December 2024
Patricia Andrés Ibarrola, Hospital Universitario de Cruces, Cruces Plaza, s/n, 48903 Barakaldo, Bizkaia, Spain.
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