Unlabelled: 1. GABAergic mechanisms have been generally ignored in the study of mood disorders and antidepressant drug (AD) action. Recently data have accumulated indicating that GABAergic mechanisms may be involved in both of these. 2. Mood disorders: GABA levels are reported to be low in the CSF and plasma of depressed patients and are related to mood changes. GABAB receptors are decreased in the frontal cortex in two rodent behavioral models of depression and GABA release is reported diminished in the hippocampus. GABAergic drugs (progabide, fengabine) reverse the behavioral deficits in the rodent models and exert clear therapeutic effects in depressed patients. 3. AD action: In behavioral models imipramine upregulates GABAB receptors only in those animals which respond behaviorally to the AD. In naive rats repeated administration of varied ADs upregulates GABAB receptors in the frontal cortex whereas non-ADs (including amphetamine) do not. Bicuculline inhibits the action of imipramine in the learned helplessness model. GABAA receptor stimulation enhances noradrenaline release in the ventral NA pathway. 4.
Conclusions: GABAergic mechanisms likely play a role in the modulation of mood and increasing GABAergic tone exerts and antidepressant effect. Actions at GABA synapses appear to be a fundamental facet of ADs, perhaps together with beta-adrenoceptor mediated events.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0278-5846(89)90123-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A comprehensive review of the neurological effects of anethole.
IBRO Neurosci Rep
June 2025
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
Since ancient times many countries have employed medicinal plants as part of traditional medicine. Anethole is a substance found in various plants and has two isomers, cis-anethole (CA) and trans-anethole (TA). Currently, the food industry extensively use anethole as an aromatic and flavoring component.
View Article and Find Full Text PDFA global overview of shared genetic architecture between smoking behaviors and major depressive disorder in European and East Asian ancestry.
J Affect Disord
January 2025
Department of Environmental Genomics, School of Public Health, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. Electronic address:
Background: The co-occurrence of smoking behaviors and major depressive disorder (MDD) has been widely documented in populations. However, the underlying mechanism of this association remains unclear.
Methods: Genome-wide association studies of smoking behaviors and MDD, combined with multi-omics datasets, were usedto characterise genetic correlations, identify shared loci and genes, and explore underlying biological mechanisms.
The role of neuroinflammation in PV interneuron impairments in brain networks; implications for cognitive disorders.
Rev Neurosci
January 2025
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Children's Medical Center Hospital, Dr. Qarib St, Keshavarz Blvd, Tehran 14194, Iran.
Fast spiking parvalbumin (PV) interneuron is an inhibitory gamma-aminobutyric acid (GABA)ergic interneuron diffused in different brain networks, including the cortex and hippocampus. As a key component of brain networks, PV interneurons collaborate in fundamental brain functions such as learning and memory by regulating excitation and inhibition (E/I) balance and generating gamma oscillations. The unique characteristics of PV interneurons, like their high metabolic demands and long branching axons, make them too vulnerable to stressors.
View Article and Find Full Text PDFParvalbumin interneurons in the anterior cingulate cortex exhibit distinct processing patterns for fear and memory in rats.
Heliyon
January 2025
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China.
The anterior cingulate cortex is responsible for multiple cognitive functions like fear, pain management, decision-making, risk and reward assessment, and memory consolidation. However, its cell-type-specific functions are not clearly understood. To reveal the selective functional role of Parvalbumin-expressing GABAergic interneurons in the ACC, we knocked down (KD) the PV gene in-vivo in rats.
View Article and Find Full Text PDFEvolutionary origins of synchronization for integrating information in neurons.
Front Cell Neurosci
January 2025
The Research Center for Brain Function and Medical Engineering, Asahikawa Medical University, Asahikawa, Japan.
The evolution of brain-expressed genes is notably slower than that of genes expressed in other tissues, a phenomenon likely due to high-level functional constraints. One such constraint might be the integration of information by neuron assemblies, enhancing environmental adaptability. This study explores the physiological mechanisms of information integration in neurons through three types of synchronization: chemical, electromagnetic, and quantum.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!