We present here a technological platform for engineering Au nanotopographies by templated electrodeposition on antibacterial surfaces. Three different types of nanostructures were fabricated: nanopillars, nanorings and nanonuggets. The nanopillars are the basic structures and are 50 nm in diameter and 100 nm in height. Particular arrangement of the nanopillars in various geometries formed nanorings and nanonuggets. Flat surfaces, rough substrate surfaces, and various nanostructured surfaces were compared for their abilities to attach and kill bacterial cells. Methicillin-resistant Staphylococcus aureus, a Gram-positive bacterial strain responsible for many infections in health care system, was used as the model bacterial strain. It was found that all the Au nanostructures, regardless their shapes, exhibited similar excellent antibacterial properties. A comparison of live cells attached to nanotopographic surfaces showed that the number of live S. aureus cells was <1% of that from flat and rough reference surfaces. Our micro/nanofabrication process is a scalable approach based on cost-efficient self-organization and provides potential for further developing functional surfaces to study the behavior of microbes on nanoscale topographies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c5nr06157a | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhancing Hydrogen Evolution Reaction through Coalescence-Induced Bubble Departure on Patterned Gold-Silicon Microstrip Surfaces.
ACS Appl Mater Interfaces
January 2025
Department of Mechanical Engineering, Boston University, 110 Cummington Mall, Boston, Massachusetts 02215, United States.
Hydrogen bubble adhesion to the electrode presents a major obstacle for green hydrogen generation via the hydrogen evolution reaction (HER) as it would induce undesired overpotential and undermine the reaction efficiency by reducing reaction area, increasing transport resistance, and creating an undesired ion concentration gradient. While electrodes with aerophobic/hydrophilic surfaces have been developed to facilitate bubble detachment, they primarily rely on micro- and nanostructured catalyst surfaces to enhance buoyance-induced bubble departure. Here, we demonstrate that introducing nonreactive yet more hydrophilic surfaces can promote coalescence-induced bubble departure, thereby significantly reducing the transport overpotential and improving HER performance.
View Article and Find Full Text PDFEnhancing the CO Oxidation Performance of Copper by Alloying with Immiscible Tantalum.
ACS Appl Mater Interfaces
January 2025
School of Materials and Energy, Lanzhou University, Lanzhou 730000, China.
Copper-tantalum (Cu-Ta) immiscible alloy nanoparticles (NPs) have been the subject of extensive research in the field of structural materials, due to their exceptional nanostructural stability and high-temperature creep properties. However, Cu is also a highly active oxidation catalyst due to its abundant valence changes. In this study, we have for the first time obtained homogeneous CuTa ( = 0.
View Article and Find Full Text PDFMultiple crosslinked, self-healing, and shape-adaptable hydrogel laden with pain-relieving chitosan@borneol nanoparticles for infected burn wound healing.
Theranostics
January 2025
Department of Radiology, Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Air Force Medical University, Xi'an, 710038, Shaanxi, China.
Next-generation wound dressings with multiple biological functions hold promise for addressing the complications and pain associated with burn wounds. A hydrogel wound dressing loaded with a pain-relieving drug was developed for treating infected burn wounds. Polyvinyl alcohol chemically grafted with gallic acid (PVA-GA), sodium alginate chemically grafted with 3-aminobenzeneboronic acid (SA-PBA), Zn, and chitosan-coated borneol nanoparticles with anti-inflammatory and pain-relieving activities were combined to afford a nanoparticle-loaded hydrogel with a PVA-GA/Zn/SA-PBA network crosslinked via multiple physicochemical interactions.
View Article and Find Full Text PDFTherapeutic Innovations in Nanomedicine: Exploring the Potential of Magnetotactic Bacteria and Bacterial Magnetosomes.
Int J Nanomedicine
January 2025
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center RAS, Kazan, Russian Federation.
Nanotechnology has emerged as a revolutionary domain with diverse applications in medicine, and one of the noteworthy developments is the exploration of bacterial magnetosomes acquired from magnetotactic bacteria (MTB) for therapeutic purposes. The demand for natural nanomaterials in the biomedical field is continuously increasing due to their biocompatibility and eco-friendly nature. MTB produces uniform, well-ordered magnetic nanoparticles inside the magnetosomes, drawing attention due to their unique and remarkable features.
View Article and Find Full Text PDFStrategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration.
Int J Nanomedicine
January 2025
Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA.
Poor aqueous solubility and bioavailability limit the translation of new drug candidates into clinical applications. Nanocrystal formulations offer a promising approach for improving the dissolution rate and saturation solubility. These formulations are applicable for various routes of administration, with each presenting unique opportunities and challenges posed by the physiological barriers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!