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Can transcutaneous electrical nerve stimulation improve achilles tendon healing in rats? | LitMetric

Can transcutaneous electrical nerve stimulation improve achilles tendon healing in rats?

Braz J Phys Ther

Departamento de Cirurgia Plástica, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Published: June 2017

AI Article Synopsis

  • Tendon injuries are common in sports, and while TENS (Transcutaneous Electrical Nerve Stimulation) is used for pain relief, its effects on tendon healing are not well understood.
  • The study focused on 60 rats with partial Achilles tendon ruptures, comparing those treated with TENS to a control group, assessing healing at 7, 14, and 21 days post-injury.
  • Results showed that TENS therapy reduced collagen types I and III production and negatively affected collagen fiber alignment during the healing process.

Article Abstract

Background: Tendon injury is one of the most frequent injuries in sports activities. TENS is a physical agent used in the treatment of pain but its influence on the tendon's healing process is unclear.

Objective: To evaluate the influence of TENS on the healing of partial rupture of the Achilles tendon in rats.

Method: Sixty Wistar rats were submitted to a partial rupture of the Achilles tendon by direct trauma and randomized into six groups (TENS or Sham stimulation) and the time of evaluation (7, 14, and 21 days post-injury). Burst TENS was applied for 30 minutes, 6 days, 100 Hz frequency, 2 Hz burst frequency, 200 µs pulse duration, and 300 ms pulse train duration. Microscopic analyses were performed to quantify the blood vessels and mast cells, birefringence to quantify collagen fiber alignment, and immunohistochemistry to quantify types I and III collagen fibers.

Results: A significant interaction was observed for collagen type I (p=0.020) where the TENS group presented lower percentage in 14 days after the lesion (p=0.33). The main group effect showed that the TENS group presented worse collagen fiber alignment (p=0.001) and lower percentage of collagen III (p=0.001) and the main time effect (p=0.001) showed decreased percentage of collagen III at 7 days (p=0.001) and 14 days (p=0.001) after lesion when compared to 21 days.

Conclusions: Burst TENS inhibited collagen I and III production and impaired its alignment during healing of partial rupture of the Achilles tendon in rats.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668336PMC
http://dx.doi.org/10.1590/bjpt-rbf.2014.0107DOI Listing

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