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Heme oxygenase/carbon monoxide system affects the placenta and preeclampsia.
Med Gas Res
June 2025
Department of Surgery, Queen Elizabeth Central Hospital, Blantyre, Malawi.
Preeclampsia affects 2% to 8% of pregnancies worldwide and results in significantly high maternal and perinatal morbidity and mortality, with delivery being the only definitive treatment. It is not a single disorder, but rather a manifestation of an insult(s) to the uteroplacental unit -whether maternal, fetal, and/or placental. Multiple etiologies have been implicated, including uteroplacental ischemia, maternal infection and/or inflammation, maternal obesity, sleep disorders, hydatidiform mole, maternal intestinal dysbiosis, autoimmune disorders, fetal diseases, breakdown of maternal-fetal immune tolerance, placental aging, and endocrine disorders.
View Article and Find Full Text PDFPatterns of Adherence to Home Blood Pressure Monitoring Among Older Adults With Ischemic Heart Disease: An Analysis From the RESILIENT Trial of Mobile Health Cardiac Rehabilitation.
J Cardiopulm Rehabil Prev
January 2025
Author Affiliations: Department of Medicine, University of Massachusetts Chan Medical School, UMass Memorial Medical Center, Worcester, Massachusetts (Drs Kovell, Bothwick, and Revoori); Division of Cardiology, Department of Medicine, Saint Vincent Hospital, Worcester, Massachusetts (Dr McCabe); Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Massachusetts (Dr Juraschek); Leon H. Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, New York, New York (Mss Meng and Pena and Dr Dodson); Institute for Excellence in Health Equity, Department of Population Health, NYU Grossman School of Medicine, New York, New York (Dr Schoenthaler); and Division of Biostatistics, Department of Population Health, NYU Grossman School of Medicine, New York, New York (Dr Adhikari).
Article Synopsis
- Hypertension is a significant risk factor for ischemic heart disease in older adults, and effective home blood pressure monitoring (HBPM) is crucial for management, especially within mobile health cardiac rehabilitation (mHealth-CR).
- A study analyzed the engagement patterns of 111 older adults participating in mHealth-CR, revealing three distinct patterns of HBPM adherence: high engagement, gradual decline, and sustained baseline engagement.
- Results indicated that overall HBPM adherence was low, declining in two engagement groups, and only depression significantly influenced weekly monitoring adherence, suggesting a need to improve motivation and support for older adults in managing their blood pressure.
Luteolin protects against myocardial ischemia/reperfusion injury by reducing oxidative stress and apoptosis through the p53 pathway.
J Integr Med
November 2024
Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China; China-Russia Medical Research Center for Stress Immunology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. Electronic address:
Objective: Myocardial ischemia/reperfusion injury (MIRI) is an obstacle to the success of cardiac reperfusion therapy. This study explores whether luteolin can mitigate MIRI by regulating the p53 signaling pathway.
Methods: Model mice were subjected to a temporary surgical ligation of the left anterior descending coronary artery, and administered luteolin.
Longitudinal trajectories of blood glucose and 30-day mortality in patients with diabetes mellitus combined with acute myocardial infarction: A retrospective cohort analysis of the MIMIC database.
PLoS One
September 2024
Department of Traditional Chinese Medicine, Xuhui District Central Hospital, Shanghai, P.R. China.
Background: Although blood glucose changes have been suggested to be a potential better target for clinical control than baseline blood glucose levels, the association of blood glucose changes with the prognosis in acute myocardial infarction (AMI) patients with diabetes mellitus (DM) is unclear. Herein, this study aimed to investigate association of short-term longitudinal trajectory of blood glucose with 30-day mortality in this population.
Methods: Data of AMI patients with DM were extracted from the Medical Information Mart for Intensive Care (MIMIC) database in 2003-2019 in this retrospective cohort study.
Ischemic-Preconditioning Induced Serum Exosomal miR-133a-3p Improved Post-Myocardial Infarction Repair via Targeting LTBP1 and PPP2CA.
Int J Nanomedicine
September 2024
Department of Anesthesiology, Maternal and Child Medical Center of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Background: Ischemic preconditioning-induced serum exosomes (IPC-exo) protected rat heart against myocardial ischemia/reperfusion injury. However, whether IPC-exo regulate replacement fibrosis after myocardial infarction (MI) and the underlying mechanisms remain unclear. MicroRNAs (miRs) are important cargos of exosomes and play an essential role in cardioprotection.
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