[Significance of low osmolarity contrast media in state of the art roentgen diagnosis].

The authors used low-osmolality contrast material intravascularly in 546 patients, in 371 cases ioxaglate, in 80 patients iopamidol and in 95 iohexol. On each occasion good detail-rich pictures were obtained. Sensation of heat was indicated only by 1 patient (iopamidol), pain by 7 patients (ioxaglate 4, iohexol 2, iopamidol 1). The blood pressure, pulse rate and the UN, SGOT and SeBiru values showed no significant changes. The experiments were carried out on 101 dog kidneys. Selective renal angiography was done with the aforementioned materials and compared with the conventional, high-osmolality materials (iodamide, metrizoate). The histological changes were only slight, of small extent, and reversible when the new materials were used. Use of the new, low-osmolality contrast materials is justified whenever they must be given intravascularly, but it is imperative in the examination of children, patients of high risk groups and sensitive organs (nervous system, kidney, coronary vessels).