AI Article Synopsis
- Glioblastoma is a serious and aggressive brain tumor, and carboplatin chemotherapy has limited effectiveness due to its low tissue concentration when given intravenously.
- This study tested whether using ultrasound to open the blood-brain barrier could increase the concentration of carboplatin in the brain of a primate model.
- Results showed that ultrasound significantly boosted the platinum levels in targeted brain areas, suggesting potential for improved treatment of brain tumors, which is currently being tested in a clinical trial.
Article Abstract
Purpose: Glioblastoma is both the most common and aggressive primary brain tumor in adults. Carboplatin chemotherapy has shown only modest efficacy in progressive high-grade gliomas. The limited clinical efficacy of carboplatin may be due to its low concentration in tissue when the drug is delivered intravenously. The aim of this study was to assess whether the tissue concentration of intravenously administered carboplatin could be enhanced by ultrasound-induced blood-brain disruption in a primate model.
Methods: Carboplatin was administered intravenously for 60 min to a single primate following blood-brain barrier opening induced by an implantable ultrasound device. Blood and brain samples were collected after animal killing, which occurred 60 min after the end of carboplatin administration. Platinum quantification in ultrafiltrate plasma and brain samples was performed using inductively coupled plasma mass spectrometry.
Results: The brain concentration of platinum was highly enhanced (5.2×) in the 3.9 cm(3) region sonicated by the US beam, with a higher concentration in more vascularized anatomical structures. At 5 and 10 mm from the US beam axis, platinum concentrations were slightly enhanced (2.2× and 1.3× respectively).
Conclusions: This study demonstrates that BBB opening using an implantable ultrasound transducer enhances the brain distribution of carboplatin in a loco-regional manner. Such a treatment approach is of significant interest for the treatment of primary brain tumors and is under current evaluation in a phase 1 clinical trial (NCT02253212).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00280-015-2930-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Trueness of tooth modified scan bodies as a novel technique for edentulous full arch implant supported dental prosthesis: an in vivo prospective comparative study.
BMC Oral Health
January 2025
Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Assiut University, Assiut, Egypt.
Objective: This study aimed to evaluate the clinical performance (degree of trueness) of a novel scan body "tooth-modified Scan body" (TMSB)& conventional scan body (CSB) in implant-supported full arch screw retained cases.
Methods: Seven edentulous arches (two maxillae, five mandibles) in 6 patients were rehabilitated with monolithic zirconia screw-retained implant prostheses supported by 4 (n = 1) and 5 implants (n = 6) for a total amount of 34 implants. Implant locations were scanned by intra-oral scanner (IOS) using two types of scan bodies, conventional scan bodies (CSB) in group (1) and tooth-modified scan bodies (TMSB) in group (2).
Outcome and safety 90 days after combined airway valve treatment of the right upper and middle lobes in patients with severe pulmonary emphysema.
Respir Res
January 2025
Department of Pneumology and Critical Care Medicine, Thoraxklinik at the University Hospital Heidelberg, Heidelberg, Germany.
Background: In COPD patients with severe right-sided emphysema, complete major and incomplete minor fissure, implantation of one-way valves in both the right upper (RUL) and middle lobes (ML) is a possible approach for endoscopic lung volume reduction. The aim of this retrospective analysis was to evaluate the response to therapy and the complication rate at 90 days (90d-FU) after combined RUL-ML valve implantation.
Methods: This retrospective, monocentric study included all patients from the Thoraxklinik Heidelberg who underwent RUL-ML valve treatment between 2012 and 2023 with available follow-up data.
A mouse model of deep vein thrombosis by inferior vena cava hypoperfusion using ameroid constrictors.
Sci Rep
January 2025
Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, 2-3-2 Nakao, Asahi-ku, Yokohama, 241-8515, Kanagawa, Japan.
Traditional mouse models for deep vein thrombosis (DVT), frequently utilized in research focused on cancer-associated thrombosis (CAT), reliably induce thrombus formation by obstructing blood flow (BF) in the inferior vena cava (IVC), which does not occur in humans. Therefore, to develop a new DVT model for CAT studies, we implanted an ameroid constrictor (AC), a hygroscopic casein C-shape device, around the IVC and aorta of immunocompromised mice. We evaluated the thrombus 3 and 8 days post-AC implantation and compared it with the traditional model 2 days post-vena cava ligation.
View Article and Find Full Text PDFA retrospective comparative study of the clinical and radiological outcomes of intertrochanteric fractures treated with proximal femoral nail antirotation (PFN-A) and INTERTAN nail.
PLoS One
January 2025
Çukurova University Faculty of Medicine, Department of Orthopedics and Traumatology, Adana, Türkiye.
Background: This study aimed to analyze the files of patients treated using PFN-A or INTERTAN intramedullary nails to reveal additional superiorities or disadvantageous factors for selecting the better intramedullary fixation method in patients presenting with intertrochanteric femur fractures.
Methods: In this retrospective study, the files of the patients who were operated on for intertrochanteric femur fractures using intramedullary fixation methods between September 2010 and June 2015 in the Orthopedics and Traumatology Clinic, Çukurova University Faculty of Medicine, were reviewed. The data including age, gender, chronic diseases, causes of fractures, fracture classification based on Arbeitsgemeinschaft für Osteosynthesefragen (AO), the nail type (long or short), the interval between trauma and surgery, duration of anesthesia and surgery, hospitalization duration, amount of blood transfusion, the Tip-Apex Distance (TAD) in postoperative radiographs, functional outcomes according to Harris Hip Score (HHS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), postoperative complications, need for revision, and mortality was noted.
Association of Gingival Thickness With Incisor Morphological Characteristics and Papilla Height: A Cross-Sectional Study.
J Esthet Restor Dent
January 2025
Department of Orthodontics and Dentofacial Orthopedics, 251 Hellenic Air Force & VA General Hospital, Athens, Greece.
Objective: The aim of the current study was to examine possible associations between gingival thickness and other parameters, such as crown length and width, papilla height and patient's age and gender.
Overview: This cross-sectional study included 238 consecutive white Caucasian consecutive patients in all stages of orthodontic treatment (before, in-course, and after orthodontic treatment). Measurements of gingival thickness were carried out at both central mandibular incisors, mid-facially on the buccal aspect of each tooth, and 2 mm apically to the free gingival margin, with an Ultrasound device.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!