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Introduction: With the introduction of increasingly powerful audio equipment and increase of personal mobile audio devices in the 21st century, the prevalence of noise-induced hearing loss (NIHL) in young adults is expected to increase. This increase, estimated to impact 30 million adults in the next four decades, is due in part to recreational exposure. While many young adults have a general understanding of NIHL, a detailed education on various topics of NIHL could further promote adherence to the use of preventive measures.
View Article and Find Full Text PDFWheat and barley serve as significant nutrient-rich staples that are extensively grown on a global scale, spanning over 219 million hectares. The annual combined global yield is 760.9 million tons, with Kazakhstan contributing 14.
View Article and Find Full Text PDFTFAP2A Activates ADAM8 to Promote Lung Adenocarcinoma Angiogenesis Through the JAK/STAT Signaling Pathway.
J Biochem Mol Toxicol
January 2025
Department of Two Branches Outside, The First People's Hospital of Yongkang, Yongkang, China.
As the most prevalent subtype of lung cancer, lung adenocarcinoma (LUAD) is closely associated with angiogenesis, which is fundamental to its progression. ADAM8 (A disintegrin and metalloproteinase 8) is an enzyme associated with tumor invasion, while its implications in LUAD angiogenesis are a field that awaits exploration. A thorough investigation into the impacts of ADAM8 on LUAD angiogenesis could contribute to the development of therapeutic drugs for LUAD.
View Article and Find Full Text PDFComparative efficacy of sodium oxybate versus placebo on improvement of nighttime sleep in adult patients with narcolepsy: A systematic review and meta-analysis.
Sleep Med X
December 2025
Hamad Medical Corporation, Doha, Qatar.
Background: Narcolepsy, a central hypersomnolence disorder, disrupts sleep regulation. Sodium oxybate, a CNS (central nervous system) depressant, is widely used as a treatment, but there are surprisingly very few rigorous studies comparing its effectiveness to placebo in adults.
Objectives: To measure the comparative efficacy of sodium oxybate at a dosage regimen of 9 g versus placebo in improving nighttime sleep quality, reducing nocturnal arousals and sleep stage shifts, and enhancing the overall refreshed nature of sleep in adult patients with narcolepsy.
What drives farmers' behavior under climate change? Decoding risk awareness, perceived impacts, and adaptive capacity in northern Italy.
Heliyon
January 2025
Environmental Intelligence for Global Change Lab, Department of Electronics, Information and Bioengineering, Politecnico di Milano, Via Ponzio 34/5, 20133, Milan, Italy.
Understanding climate change in a precise and timely manner may assist in gauging the occurrence and seriousness of its impacts, thereby boosting the adaptive capacity and responsiveness of farmers. This investigation looks into farmers' knowledge of climate change, their perception of risks and impacts, and the strategies they anticipate to tackle the challenges of adaptation. A well-structured online survey covering risk awareness, perception, and adaptation was used to randomly sample 460 respondents from 12 irrigation districts in northern Italy.
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