AI Article Synopsis
- The study focuses on biofunctional scaffolds that enhance the growth and development of mesenchymal stem cells (MSCs) for bone tissue engineering.
- Researchers used an easy UV-crosslinking method to create gelatin electrospun fibrous (GEF) scaffolds that include important biomolecules like RGD peptide, hydroxyapatite nanoparticles, and BMP-2.
- The presence of these biomolecules significantly boosts MSC adhesion, proliferation, and differentiation, suggesting a promising approach for designing effective scaffolds in tissue engineering.
Article Abstract
Biofunctional scaffolds that support the adhesion, proliferation, and osteo-differentiation of mesenchymal stem cells (MSCs) are critical for bone tissue engineering. In this study, a simple in situ UV-crosslinking strategy was utilized to fabricate gelatin electrospun fibrous (GEF) scaffolds with multiple biosignals, including cell adhesive Arg-Gly-Asp (RGD) peptide, osteo-conductive hydroxyapatite (HAp) nanoparticles, and osteo-inductive bone morphogenic protein-2 (BMP-2). The adhesion and proliferation of MSCs on the GEF scaffolds were improved by the incorporation of RGD. Meanwhile, the incorporation of HAp and BMP-2 enhanced osteo-differentiation of MSCs. The three incorporated bio-factors exert a synergistic effect on osteogenesis of MSCs in the GEF scaffolds. This strategy of incorporating multiple biomolecules could be used to fabricate crosslinked electrospun scaffolds of natural polymers for tissue-engineering applications.
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| http://dx.doi.org/10.1016/j.colsurfb.2015.11.017 | DOI Listing |
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