The Republic of Kazakhstan is one of the fastest developing countries in the world and has a health care system that is unique in Central Asia. Its organ transplant services are also developing rapidly. We aimed to analyze and briefly report on the current status of organ transplant in the Republic of Kazakhstan. We analyzed organ transplant activities in that country for the period 2012 to 2014. All data were collected from the official database of the National Transplant Coordinating Center of the Republic of Kazakhstan. At the end of 2014, the number of transplant centers had increased to 10, three of which could perform multiorgan transplants; during the same period, the number of deceased-donor organ-donating hospitals increased up to 37. By 2013, the transplant activity rate for all centers had reached 9.22 per million population. During the previous 3 years (2012-2014), there was a 3-fold increase in the number of living donors and an 18-fold increase in the number of kidney transplants. Between 2012 and 2014, the number of living-donor liver transplants increased from 17 to 25, and the number of deceased-donor transplants increased from 3 to 7. During the last 3 years (2012-2014), the number of heart transplants increased to 7 cases. During the last 3 years (2012-2014), Kazakhstan achieved a significant improvement in the organization of its transplant services, and a noticeable upward trend in the system continues.
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http://dx.doi.org/10.6002/ect.tdtd2015.L5 | DOI Listing |
JAMA Cardiol
January 2025
Brigham and Women's Hospital Heart and Vascular Center, Center for Advanced Heart Disease, Harvard Medical School, Boston, Massachusetts.
Importance: The Aspirin and Hemocompatibility Events With a Left Ventricular Assist Device in Advanced Heart Failure (ARIES-HM3) study demonstrated that aspirin may be safely eliminated from the antithrombotic regimen after HeartMate 3 (HM3 [Abbott Cardiovascular]) left ventricular assist device (LVAD) implantation. This prespecified analysis explored whether conditions requiring aspirin (prior percutaneous coronary intervention [PCI], coronary artery bypass grafting [CABG], stroke, or peripheral vascular disease [PVD]) would influence outcomes differentially with aspirin avoidance.
Objective: To analyze aspirin avoidance on hemocompatibility-related adverse events (HRAEs) at 1 year after implant in patients with a history of CABG, PCI, stroke, or PVD.
Polymers (Basel)
December 2024
Limited Liability Partnership «Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan», Karaganda 100008, Kazakhstan.
Zinc-imprinted polymer (ZnIP) and non-imprinted polymer (NIP) were synthesized by radical polymerization, and their properties were studied. The novelty of the work lies in the use of humic acids isolated from coals of the Shubarkol deposit (Karaganda, Kazakhstan) as a basis for the imprinted polymer matrix, with methacrylic acid and ethylene glycol dimethacrylate as a functional monomer and a cross-linking agent, respectively. The composition and structure of ZnIP and NIP were characterized using various physicochemical methods.
View Article and Find Full Text PDFPharmaceuticals (Basel)
December 2024
BK21 FOUR Team and Integrated Research, Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
Parkinson's disease (PD) is a chronic, progressive neurological disorder affecting approximately 10 million people worldwide, with prevalence expected to rise as the global population ages. It is characterized by the degeneration of dopamine-producing neurons in the substantia nigra pars compacta, leading to motor symptoms such as tremor, rigidity, bradykinesia, postural instability, and gait disturbances, as well as non-motor symptoms including olfactory disturbances, sleep disorders, and depression. Currently, no cure exists for PD, and most available therapies focus on symptom alleviation.
View Article and Find Full Text PDFPharmaceuticals (Basel)
November 2024
School of Pharmacy, Karaganda Medical University, Gogol Street, 40, Karaganda 100012, Kazakhstan.
This review is devoted to a systematic analysis of studies aimed at investigating plant extracts, essential oils and phytochemical compounds capable of inhibiting biofilm formation. This paper investigates the effect of extracts, essential oils and individual plant compounds on inhibiting the biofilm formation of , one of the major pathogens responsible for the development of dental caries. Using cultural microbiology and molecular biology techniques, the authors describe the mechanisms by which plant samples reduce adhesion and growth.
View Article and Find Full Text PDFMolecules
December 2024
Department of Chemistry, Biology and Ecology, Central Asian Innovation University, Shymkent 160000, Kazakhstan.
Cellulose-based sorbents are promising materials for wastewater treatment due to their environmental friendliness, biodegradability, and high sorption capacity. This paper presents an overview of cellulose modification methods, including carboxylation, amination, oxidation, graphene, and plasma treatments, as well as combined approaches. Their effect on key physicochemical properties, such as porosity, morphology, and chemical stability, is considered.
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