Polygonum multiflorum is a traditional Chinese medicine with a long history in hair growth promotion and hair blackening. The purpose of the study was to examine the effect and the mechanism of Polygonum multiflorum in hair blackening. C57BL/6 mice hair fade was induced with H2O2 and used in this research. Hair pigmentogenesis promotion activities of Polygonum Multiflorum Radix (PMR, raw crude drug), Polygonum Multiflorum Radix Preparata (PMRP, processed crude drug), and their major chemical constituent TSG were investigated. The regulation effects of several cytokines and enzymes such as POMC, α-MSH, MC1R, ASIP, MITF, TYR, TRP-1, and TRP-2 were investigated. PMR group gave out the most outstanding black hair among all groups with the highest contents of total melanin, α-MSH, MC1R, and TYR. Promotion of hair pigmentogenesis was slightly decreased after processing in the PMRP group. TSG as the major constituent of PMR showed weaker hair color regulation effects than both PMR and PMRP. PMR, but not PMRP, should be used to blacken hair. The α-MSH, MC1R, and TYR were the major targets in the medicinal use of PMR in hair graying. Chemical constituents other than TSG may contribute to the hair color regulation activity of PMR.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657090 | PMC |
| http://dx.doi.org/10.1155/2015/651048 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extracellular Vesicle-Like Nanovesicle for Skin Photoaging Therapy.
Biomater Res
December 2024
Center for Plastic & Reconstructive Surgery, Department of Dermatology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
Ultraviolet (UV) irradiation leads to the degradation of the extracellular matrix and collagen, thereby accelerating skin aging and imposing substantial psychological burden on patients. Current anti-aging strategies are limited and often associated with high costs or strong side effects. Plant-derived extracellular vesicle-like nanovesicles, with advantages such as natural availability and cost-effectiveness, show potential in anti-aging interventions.
View Article and Find Full Text PDFIntegrated multi-omics analyses combined with western blotting discovered that cis-TSG alleviated liver injury via modulating lipid metabolism.
Front Pharmacol
November 2024
State Key Laboratory of Component-based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
shows dual hepatoprotective and hepatotoxic effects. The bioactive components responsible for these effects are unknown. This study investigates whether -2,3,5,4'-tetrahydroxystilbene-2-O--D-glucoside (-TSG), a stilbene glycoside, has hepatoprotective and/or hepatotoxic effects in a liver injury model.
View Article and Find Full Text PDFTi-based MOF nanosheets as a mass spectrometry imaging matrix for low molecular weight compounds to reveal the spatiotemporal content changes of hepatotoxic components during the processing of .
Analyst
December 2024
School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, P. R. China.
Article Synopsis
- The study focuses on developing metal-organic framework (MOF) matrices to enhance matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) for analyzing small molecules, particularly hepatotoxic compounds.
- Ti-based MOF nanosheets were found to have advantages over traditional organic matrices, showing less background noise, greater stability, and better salt resistance during imaging.
- The research demonstrated that these MOF nanosheets improved detection of specific hepatotoxic components during the steaming process, revealing their unique spatial distribution and contributing valuable insights for the study of small molecules.
Processing-induced reduction in dianthrones content and toxicity of Polygonum multiflorum: Insights from ultra-high performance liquid chromatography triple quadrupole mass spectrometry analysis and toxicological assessment.
Animal Model Exp Med
October 2024
New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Background: Polygonum multiflorum-induced liver injury (PM-DILI) has significantly hindered its clinical application and development.
Methods: This study investigates the variation in content and toxicity of dianthrones, the toxic components of P. multiflorum, during different processing cycles.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!