AI Article Synopsis
- Hematopoietic chimeras, genetically compatible with skin-graft donors, still reject grafts due to differences in skin-selective alloantigens.
- Research involved monoclonal antibodies that identify the Skna alloantigen to assess its presence in skin samples.
- Results showed that Skna alloantigen is present on the epidermal cells of Skna genotype skin, but absent in non-Skna genotype skin.
Article Abstract
Rejection of murine skin grafts by hematopoietic chimeras that are fully compatible genetically with the skin-graft donor has been attributed to a disparity in skin-selective alloantigens between the irradiated host and the skin graft donor. Monoclonal antibodies recognizing Skna alloantigen were produced and used in indirect immunofluorescent and immunoperoxidase tests with sections of skin to demonstrate and confirm the expression of Skna alloantigen on epidermal cells of Skna genotype and absence of Skna alloantigen from epidermal cells of non-Skna genotype.
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| http://dx.doi.org/10.1111/1523-1747.ep12277343 | DOI Listing |
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Department of Microbiology, University of New Mexico, School of Medicine, Albuquerque, NM 87131.
Article Synopsis
- Hematopoietic chimeras, genetically compatible with skin-graft donors, still reject grafts due to differences in skin-selective alloantigens.
- Research involved monoclonal antibodies that identify the Skna alloantigen to assess its presence in skin samples.
- Results showed that Skna alloantigen is present on the epidermal cells of Skna genotype skin, but absent in non-Skna genotype skin.
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