Accumulation of pro-aggregation substances in the incubation medium of isolated UV-irradiated rabbit leukocytes showed stronger correlation with photo-induced apoptotic death of leukocytes (r=0.92) than with their photo-induced necrotic death (r=0.70). It can be suggested that pro-aggregation substances release form leukocytes exposed to irradiation during preparation of these cells to apoptosis after UV irradiation.
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http://dx.doi.org/10.1007/s10517-015-3129-9 | DOI Listing |
Environ Int
September 2021
Department of Medicine and Unit of Andrology and Reproduction Medicine, University of Padova, Padova, Italy. Electronic address:
Background: Health concerns associated with the exposure to legacy perfluoro-alkyl substances (PFAS) led to the development of new-generation PFAS, such as C6O4. Here we investigated the possible effects of C6O4 on the platelet's activation profile, by incubating human platelets from healthy donors with C6O4 at different concentrations and evaluating the effects on activation, production and phenotype of platelets micro-particles (MPV) and aggregation under-flow. Based on the eventual platelet pro-aggregation profile detected, the preventive effect of acetylsalicylic acid (ASA) was also explored.
View Article and Find Full Text PDFBull Exp Biol Med
December 2015
Department of General and Medical Biophysics, Medical and Biological faculty, N. I. Pirogov Russian National Research Medical University, Moscow, Russia.
Accumulation of pro-aggregation substances in the incubation medium of isolated UV-irradiated rabbit leukocytes showed stronger correlation with photo-induced apoptotic death of leukocytes (r=0.92) than with their photo-induced necrotic death (r=0.70).
View Article and Find Full Text PDFIt is shown that during incubation after UV irradiation (22-24 hours at 7-9 degrees C) irradiated isolated rabbit leukocytes release the compound(s) which induces platelets aggregation in the native platelet rich plasma. Treatment of the incubation media of irradiated leukocytes by heat (5 minutes at 100 degrees C) does not significantly change its pro-aggregation activity. Treatment of the platelet-rich plasma by the incubation media of irradiated leukocytes without stirring induces the refractoriness of platelets to ADP.
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