Mitochondria-targeted cationic antioxidant plastoquinonyl decyltriphenylphosphonium (SkQ1) added to drinking water in therapeutic doses (250 nmol/kg per day) for a long time (up to 24 months) does not induce cytochromes P450 in rat liver.
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Mitochondrial antioxidant SkQ1 attenuates C26 cancer-induced muscle wasting in males and improves muscle contractility in female tumor-bearing mice.
Am J Physiol Cell Physiol
November 2024
Cachexia Research Laboratory, Department of Health, Human Performance and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas, United States.
Article Synopsis
- Mitochondrial problems are linked to cancer cachexia, a condition causing muscle wasting in cancer patients.
- Researchers tested a special antioxidant called SkQ1 in mice to see if it could help reduce muscle loss caused by cancer.
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10-(6'-Plastoquinonyl)decyltriphenylphosphonium (SkQ1) Does Not Increase the Level of Cytochromes P450 in Rat Liver and Human Hepatocyte Cell Culture.
Biochemistry (Mosc)
December 2016
Lomonosov Moscow State University, Faculty of Fundamental Medicine, Moscow, 119991, Russia.
Mitochondria-targeted antioxidant SkQ1 did not increase the content of cytochromes P450 in livers of rats that were given SkQ1 in drinking water for 5 days in a dose (2.5 µmol per kg body weight) that exceeded 10 times the SkQ1 therapeutic dose. SkQ1 did not affect the levels of cytochrome P450 forms CYP1A2, CYP2B6, and CYP3A4 in monolayer cultures of freshly isolated human hepatocytes, while specific inducers of these forms (omeprazole, phenobarbital, and rifampicin, respectively) significantly increased expression of the cytochromes P450 under the same conditions.
View Article and Find Full Text PDFEffect of Long-Term Treatment with Antioxidant SkQ1 Added to Drinking Water on Cytochromes P450 Level in Rat Liver.
Biochemistry (Mosc)
December 2015
Lomonosov Moscow State University, Faculty of Fundamental Medicine, Moscow, 119991, Russia.
Mitochondria-targeted cationic antioxidant plastoquinonyl decyltriphenylphosphonium (SkQ1) added to drinking water in therapeutic doses (250 nmol/kg per day) for a long time (up to 24 months) does not induce cytochromes P450 in rat liver.
View Article and Find Full Text PDFEffect of the mitochondria-targeted antioxidant SkQ1 on development of spontaneous tumors in BALB/c mice.
Biochemistry (Mosc)
October 2014
Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119991, Russia.
The mitochondria-targeted antioxidant SkQ1 (10-(6'-plastoquinonyldecyl)triphenylphosphonium) is a new pharmaceutical substance with a wide spectrum of effects including increase in lifespan of laboratory animals (for example, of BALB/c mice males) and inhibition of development of some experimental tumors and also of tumor cell growth. In this work, the effects of SkQ1 on development of spontaneous tumors in female and male BALB/c mice housed in an SPF-class vivarium were studied. We found that the addition of SkQ1 to drinking water at the dose of 1 and 30 nmol/kg body weight per day throughout the lifespan modified the spectrum of spontaneous tumors in the female mice, decreasing the incidence of follicular lymphomas.
View Article and Find Full Text PDFTherapeutic doses of SkQ1 do not induce cytochromes P450 in rat liver.
Biochemistry (Mosc)
October 2014
Lomonosov Moscow State University, Faculty of Fundamental Medicine, Moscow, 119991, Russia.
The effect of SkQ1 (a mitochondria-targeted antioxidant) on the level of cytochromes P450 in rat liver was studied. It was found that administration of therapeutic dose of SkQ1 with drinking water for 5 days (250 nmol/kg of body weight per day) did not alter the level of cytochromes P450. Under the same conditions, the standard dose of phenobarbital used for the induction of cytochromes P450 caused the 2.
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